Abstract
The role of growth factors in central nervous system (CNS) function has been the focus of much research within the last decade. While much of the attention centered around nerve growth factor initially, other growth factors have also been shown to have a potential role in nervous system function. Among the most intriguing of these are the insulin-like growth factors I and II (IGF-I and IGF-II). As early as 1941, a report was published in which crude pituitary extracts were shown to increase the brain size of tadpoles.1 Later studies following up on this initial observation demonstrated that the trophic factor involved in this response was growth hormone (GH) dependent2 and that the factor causing the increased growth was IGF-I.3
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Lauterio, T.J. (1992). The Effects of IGF-I and IGF-II on Cell Growth and Differentiation in the Central Nervous System. In: Vinik, A.I., Sirman, D.J. (eds) Pancreatic Islet Cell Regeneration and Growth. Advances in Experimental Medicine and Biology, vol 321. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3448-8_4
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DOI: https://doi.org/10.1007/978-1-4615-3448-8_4
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