Abstract
Rous sarcoma virus (RSV), a strongly transforming avian retrovirus, induces a cellular immediate-early gene that encodes a new form of prostaglandin G/H synthase (PGHS). Other mitogens such as serum and phorbol esters also induce this isoenzyme. The RSV-induced PGHS is very similar in size to the PGHS isolated from sheep seminal vesicle, and has all the hallmarks of a PGHS, including conserved glycosylation sites, a heme binding domain, and the acetylation site for aspirin. Mitogenic stimulation of cyclooxygenase activity in NIH 3T3 cells correlates with induction of this new form of PGHS. Furthermore, dexamethasone (DEX) inhibits the mitogenic induction of RSV-induced PGHS, suggesting a new mechanism by which this steroid may exert its antiinflammatory effect. The close link between induction of this new PGHS and cell division suggests that prostaglandin/thromboxane synthesis mediated by this enzyme plays a role in mitosis.
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Simmons, D.L., Xie, W., Evett, G.E. (1993). Rous Sarcoma Virus Induces a New Form of Prostaglandin G/H Synthase (Cyclooxygenase). In: Nigam, S., Honn, K.V., Marnett, L.J., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Developments in Oncology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3520-1_15
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DOI: https://doi.org/10.1007/978-1-4615-3520-1_15
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