Abstract
2-Nitrofluorene (2-NF) is an air pollutant that is found in appreciable concentrations in urban air due to the exhaust of especially Diesel engines. Like many other nitroaromatics, it is a direct acting mutagen in bacteria that contain nitroreductase activity: this enzyme converts the nitro-aromatics to reduced products, notably the hydroxylamines, that can interact directly with DNA and can cause mutations. 2-NF is a carcinogen in the rat, especially in the forestomach, where it causes tumors upon oral administrationl–4. As yet it is unclear which metabolite(s) is (are) responsible for the mutagenic and carcinogenic activity of 2-NF.
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Mulder, G.J., Wierckx, F.C.J., Wedzinga, R., Meerman, J.H.N. (1990). Generation of Reactive Intermediates from 2-Nitrofluorene that Bind Covalently to DNA, RNA and Protein in Vitro and in Vivo in the RAT. In: Howard, P.C., Hecht, S.S., Beland, F.A. (eds) Nitroarenes. Environmental Science Research, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3800-4_20
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DOI: https://doi.org/10.1007/978-1-4615-3800-4_20
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