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Strategies for the Prevention of Treatment-Induced Secondary Cancer

  • Chapter
Anticarcinogenesis and Radiation Protection 2

Abstract

The risk of treatment-induced secondary cancer in patients with malignant disease is becoming more important as the treatment of primary tumors improves and more patients survive. A possible genetic or congenital predisposition, altered immunity, and the preceding or continuing exposure to certain other agents may add to the carcinogenic potential of chemotherapy and radiotherapy. It has been observed that aggressive, though successful, treatment protocols in particular enhance the risk. Some studies have reported that up to 20% of surviving patients develop a treatment-induced secondary cancer over a ten to fifteen year period following the control of the first malignancy. Effective means for the prevention of treatment-induced cancer are therefore needed. In this article, we discuss several strategies that may reduce the risk of treatment-induced cancer; namely, new multiple-drug regimens, proton beam therapy, application of tumor sensitizers, and the use of agents that inhibit malignant transformation.

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Author information

Authors and Affiliations

  1. Service de Radiotherapie, Centre Hospitalier Universitaire Vaudois, Lausanne, 1011, Switzerland

    Hans P. Rutz & Rene O. Mirimanoff

  2. Laboratory of Radiobiology, Harvard School of Public Health, Boston, MA, 02115, USA

    John B. Little

Authors
  1. Hans P. Rutz
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  2. Rene O. Mirimanoff
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  3. John B. Little
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Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Oddvar F. Nygaard

  2. New York University Medical Center, New York, USA

    Arthur C. Upton

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Rutz, H.P., Mirimanoff, R.O., Little, J.B. (1991). Strategies for the Prevention of Treatment-Induced Secondary Cancer. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_6

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  • DOI: https://doi.org/10.1007/978-1-4615-3850-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6718-5

  • Online ISBN: 978-1-4615-3850-9

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