Abstract
Cells from 203 childhood leukemia patients were analyzed using a broad panel of markers, such as immunological marker studies and Southern blot and Northern blot analyses to define the lineage-specific classification of childhood leukemia. Phenotypically, they were divided into B lineage (62.6%), T lineage (9.8%), nonlymphoid (14.3%), and uncertain lineage (13.3%). Two of the B-lineage ALL and two of the T-lineage ALL studied did not show immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements, respectively. Therefore those four cases were excluded from the final classification. The uncertain lineage leukemia, which includes undifferentiated leukemia and mixed lineage leukemia, could be further subclassified at the DNA and RNA levels. On the basis of these findings, we discuss the definition for B-lineage and T-lineage cells, the incidence of dual genotypes or spillover, heterogeneity of undifferentiated leukemia, and a new classification for mixed—lineage leukemia. In addition, NK—lineage leukemia associated with Epstein-Barr viral infection is also presented.
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© 1991 Springer Science+Business Media New York
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Kawa-Ha, K., Tawa, A., Yumura-Yagi, K., Hara, J., Ishihara, S. (1991). Lineage-Specific Classification of Childhood Leukemia and its Clinical Implications. In: Kobayashi, N., Akera, T., Mizutani, S. (eds) Childhood Leukemia: Present Problems and Future Prospects. Developments in Oncology, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3898-1_9
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DOI: https://doi.org/10.1007/978-1-4615-3898-1_9
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