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Molecular Mechanism of Mechanical Stress-Induced Cardiac Hypertrophy

  • Chapter
The Hypertrophied Heart

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 3))

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Summary

Mechanical stress is a major cause of cardiac hypertrophy. Although the mechanisms by which mechanical load induces cardiomyocyte hypertrophy have long been a subject of great interest for cardiologists, the lack of a good in vitro system has hampered the understanding of the biochemical mechanisms. For these past several years, however, an in vitro neonatal cardiocyte culture system has made it possible to examine the biochemical basis for the signal transduction of mechanical stress. Passive stretch of cardiac myocytes cultured on silicone membranes activates phosphorylation cascades of many protein kinases, including protein kinase C, Raf-1 kinase, and extracellular signal-regulated kinases, and induces the expression of specific genes as well as an increase in protein synthesis. During that process, secretion and production of vasoactive peptides such as angiotensin II and endothelin are increased, and these peptides play critical roles in the induction of these hypertrophic responses. However, we have recendy obtained evidence suggesting that the vasoactive peptides are not indispensable for the development of mechanical stress-induced hypertrophic responses. The most important question—how mechanical stimulus is converted into biochemical signals—remains unknown.

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Authors and Affiliations

  1. Department of Cardiovascular Mediane, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Issei Komuro

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Editors and Affiliations

  1. Department of Internal Medicine, Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda M.D., Ph.D. (Associate Professor) (Associate Professor)

  2. Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  3. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.), D.Sc. (Hon) (Distinguished Professor and Director) (Distinguished Professor and Director)

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Komuro, I. (2000). Molecular Mechanism of Mechanical Stress-Induced Cardiac Hypertrophy. In: Takeda, N., Nagano, M., Dhalla, N.S. (eds) The Hypertrophied Heart. Progress in Experimental Cardiology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4423-4_9

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  • DOI: https://doi.org/10.1007/978-1-4615-4423-4_9

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