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Hyperglycemia and Diabetes — Induced Vascular Dysfunction: Role of Oxidative Stress

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Oxidative Stress and Vascular Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 224))

Abstract

There is substantial indirect evidence that oxidative stress occurs during the course of diabetes mellitus. This is based upon reports of elevation in lipid peroxides (i.e., malondialdehyde) in plasma of experimental diabetic rodents (1–3) and in plasma of human type I and type II diabetes mellitus (2,4-7). More recently, F2-isoprostanes, nonenzymatic peroxidation products, were shown to be increased in plasma of diabetic patients (8). In addition to elevated concentrations of lipid peroxides, oxidation of LDL, increased formation of glycated proteins, and elevated plasma concentrations of ceruloplasmin (9,10) have supported a role for increased oxidative stress in diabetic patients.

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  1. Galen M. Pieper
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  1. Boston University School of Medicine, Boston, MA, USA

    John F. Keaney Jr. M.D. (Associate Professor of Medicine and Pharmacology) (Associate Professor of Medicine and Pharmacology)

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Pieper, G.M. (2000). Hyperglycemia and Diabetes — Induced Vascular Dysfunction: Role of Oxidative Stress. In: Keaney, J.F. (eds) Oxidative Stress and Vascular Disease. Developments in Cardiovascular Medicine, vol 224. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4649-8_16

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