Abstract
In the past decade, substantial attention has been directed toward understanding how reactive oxygen species contribute to the pathophysiology of vascular disease. Increasing evidence suggests that increases in vascular production of oxygenderived radicals represent a common pathway whereby many pathological conditions can promote vascular disease and lesion formation. In particular, it has become clear that reactive oxygen species play a critical role in the pathology of hypertension. Likewise, many of the neurohumoral alterations that accompany hypertension accelerate vascular production of reactive oxygen species. In this review, we will discuss this evidence and examine the potential consequences of “oxidative stress” as it pertains to hypertension and its vascular consequences.
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Somers, M.J., Griendling, K.K., Harrison, D.G. (2000). The Role of Oxidative Stress in Hypertension. In: Keaney, J.F. (eds) Oxidative Stress and Vascular Disease. Developments in Cardiovascular Medicine, vol 224. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4649-8_17
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DOI: https://doi.org/10.1007/978-1-4615-4649-8_17
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