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Evidence for Involvement of Prostaglandin I2 as a Major Nociceptive Mediator in Acetic Acid-Induced Writhing Reaction: a Study Using IP-Receptor Disrupted Mice

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 469))

Abstract

Writhing reaction of mice has been used for the evaluation of analgesics or anti-inflammatory agents (Vinegar et al., 1979). It has been suggested that there may be a putative involvement of cyclooxygenase metabolites in this model of inflammatory pain. However, it is not yet generally concluded which product of eicosanoids, including PGE2 and PGI2, is a main mediator of this pain model.

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Refferences

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Author information

Authors and Affiliations

  1. Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, 108-8641, Japan

    Sachiko Oh-ishi, Akinori Ueno & Hideki Matsumoto

  2. Department of Pharmacology, Faculty of Medicine, Kyoto University, Yoshida, Kyoto, 606-01, Japan

    Takahiko Murata, Fumitaka Ushikubi & Shuh Narumiya

Authors
  1. Sachiko Oh-ishi
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  2. Akinori Ueno
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  3. Hideki Matsumoto
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  4. Takahiko Murata
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  5. Fumitaka Ushikubi
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  6. Shuh Narumiya
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Editor information

Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California at San Diego, San Diego, California, USA

    Edward A. Dennis

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© 1999 Springer Science+Business Media New York

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Oh-ishi, S., Ueno, A., Matsumoto, H., Murata, T., Ushikubi, F., Narumiya, S. (1999). Evidence for Involvement of Prostaglandin I2 as a Major Nociceptive Mediator in Acetic Acid-Induced Writhing Reaction: a Study Using IP-Receptor Disrupted Mice. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_39

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  • DOI: https://doi.org/10.1007/978-1-4615-4793-8_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7171-7

  • Online ISBN: 978-1-4615-4793-8

  • eBook Packages: Springer Book Archive

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