Abstract
Despite an enormous body of knowledge regarding hematopoietic cell growth and differentiation and the regulation of these processes by hematopoietic growth factors, the phenomenon of progenitor cell mobilization remains an enigma. With the expectation that clinical development of blood stem cell transplantation will be greatly benefited by advances in knowledge about the specific processes which underpin mobilization, we have sought to define the limiting steps which regulate blood progenitor cell numbers following in vivo stimulation with G-CSF. This paper reviews the rationale behind the genetic approach we have chosen to take and summarises our recent promising, but preliminary, results.
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Aiuti A, Webb IJ, Bleui C, Springer T, Gutierrez-Ramos JC: The chemokine SDF-1 is a chemoattrac-tant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 185: 111, 1997.
Laterveer L, Lindley IJD, Hamilton MS, Willemze R, Fibbe WE: Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability. Blood 85: 2269, 1995.
Liu F, Poursine-Laurent J, Link DC: The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand. Blood 90: 2522, 1997.
Papayannopoulou T and Nakamoto B: Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin. Proc Natl Acad Sci USA 90: 9374, 1993.
Papayannopoulou T, Priestley G, Nakamoto B: Anti-VLA4/VCAM-1-induced mobilization requires cooperative signaling through kit/mkit ligand pathway. Blood 91: 2231, 1998.
Roberts AW, Foote S, Alexander WS, Scott C, Robb L, Metcalf D: Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor. Blood 89: 2736, 1997.
Simmons PJ, Leavesley DI, Levesque J-P, Swart BW, Haylock DN, To LB, Ashman LK, and Juttner CA: The mobilization of primitive hemopoietic progenitors into the peripheral blood. Stem Cells 12 (Suppl 1): 187, 1994.
Lander ES and Schork NJ: Genetic dissection of complex traits. Science 265: 2037, 1994.
Lander ES and Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics 11: 241, 1995.
Grigg AP, Roberts AW, Raunow H, Houghton S, Layton JE, Boyd AW, McGrath KM, Maher D: Optimising dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers. Blood 86: 4437, 1995.
Dreger P, Haferlach T, Eckstein V, Jacobs S, Suttorp M, Löffler H, Müller-Ruchholtz W, Schmitz N: G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation: safety, kinetics of mobilization, and composition of the graft. Brit J Haematol 87: 609, 1994.
Lane TA, Law P, Maruyama M, Young D, Burgess J, Mullen M, Mealiffe M, Terstappen LWMM, Hard-wick A, Moubayed M, Oldham F, Corringham RET, Ho AD: Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony-stimulating factor (GM-CSF) or G-CSF: potential role in allogeneic marrow transplantation. Blood 85: 275, 1995.
Tjønnfjord GE, Steen R, Evensen SA, Thorsby E, Egeland T: Characterization of CD34+ peripheral blood cells from health adults mobilized by recombinant human granulocyte colony-stimulating factor. Blood 84: 2795, 1994.
Roberts AW, DeLuca E, Begley CG, Basser R, Grigg AP, Metcalf D: Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating factor therapy. Stem Cells 13: 512, 1995.
Roberts AW, Hasegawa M, Metcalf D, Foote S: Genetic influences determining in vivo responses to granulocyte colony-stimulating factor, (submitted).
Muller-Sieburg CE and Riblet R: Genetic control of the frequency of hematopoietic stem cells in mice: mapping of a candidate locus to chromosome 1. J Exp Med 183: 1141, 1996.
de Haan G and van Zant G: Intrinsic and extrinsic control of hemopoietic stem cell numbers: mapping of a stem cell gene. J Exp Med 186: 529, 1997.
Phillips RL, Reinhart AJ, van Zant G: Genetic control of murine hematopoietic stem cell pool sizes and cycling kinetics. Proc Natl Acad Sci USA 89: 11607, 1992.
van Zant G, Eldridge PW, Behringer RR, Dewey MJ: Genetic control of hematopoietic kinetics revealed by analyses of allophenic mice and stem cell suicide. Cell 35: 639, 1983.
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Roberts, A.W., Foote, S., Metcalf, D. (1999). Genetic Approaches to the Investigation of the Mechanisms of Hematopoietic Progenitor Cell Mobilization into the Blood. In: Abraham, N.G., Tabilio, A., Martelli, M., Asano, S., Donfrancesco, A. (eds) Molecular Biology of Hematopoiesis 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4797-6_4
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DOI: https://doi.org/10.1007/978-1-4615-4797-6_4
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