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Bromoacetamido-Analogs of Indomethacin and Mefenamic Acid Affinity-Label Prostaglandin H2 Synthase at Two Sites

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 400))

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Abstract

Prostaglandin H2 (PGH) synthase (EC 1.14.99.1) catalyzes the bis-dioxygenation of arachidonic acid to yield PGG2 (cyclooxygenase reaction) and the peroxidative cleavage of PGG2 to yield PGH2 (peroxidase reaction). PGH synthase (Mr: 72 kDa) functions as a homodimer and is a target for nonsteroidal antiinflammatory drugs (NSAIDs), which inhibit the cyclooxygenase reaction only.

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104-6084, USA

    Mark S. Tang, Leslie J. Askonas & Trevor M. Penning

Authors
  1. Mark S. Tang
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  2. Leslie J. Askonas
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  3. Trevor M. Penning
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Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Free University Berlin, Berlin, Germany

    Santosh Nigam

  3. Vanderbilt University, Nashville, Tennessee, USA

    Lawrence J. Marnett

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© 1997 Springer Science+Business Media New York

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Tang, M.S., Askonas, L.J., Penning, T.M. (1997). Bromoacetamido-Analogs of Indomethacin and Mefenamic Acid Affinity-Label Prostaglandin H2 Synthase at Two Sites. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_11

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  • DOI: https://doi.org/10.1007/978-1-4615-5325-0_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7430-5

  • Online ISBN: 978-1-4615-5325-0

  • eBook Packages: Springer Book Archive

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