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Gap Junctions, Cardiac Excitability and Clinical Arrhythmias

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Heart Cell Communication in Health and Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 200))

Abstract

The explosive growth in our understanding of cellular electrophysiology and the relationship to clinical arrhythmias continues. Much of the basic science that concerns the role of gap junctions in arrhythmias has been reviewed in other chapters in this book. The purpose of this chapter is to create an intellectual framework for the clinician that is based on biophysical theory and to allow the researcher who is not a physician insight into clinical thought processes. The emphasis will be on the known and probable role of gap junctions in normal and abnormal cardiac excitability with an emphasis on arrhythmogenesis due to anisotropic conduction.

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  1. Cardiology Section, Department of Medicine, Pritzker School of Medicine, University of Chicago, USA

    Morton F. Arnsdorf & Samuel C. Dudley

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  1. Morton F. Arnsdorf
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Walmor C. De Mello Michiel J. Janse

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Arnsdorf, M.F., Dudley, S.C. (1998). Gap Junctions, Cardiac Excitability and Clinical Arrhythmias. In: De Mello, W.C., Janse, M.J. (eds) Heart Cell Communication in Health and Disease. Developments in Cardiovascular Medicine, vol 200. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5525-4_10

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