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Developmental Regulatlon of the Cardiac Renin-Angiotensin System: Expression and Associatlon With Growth and Apoptosis

  • Chapter
Angiotensin II Receptor Blockade Physiological and Clinical Implications

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 2))

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Summary

Identification and elucidation of the roles of humoral factors involved in cardiogenesis and other aspects of cardiac growth will be important for the overall understanding of how the heart develops and functions. Angiotensin (Ang) II has been demonstrated to have important in vivo and in vitro growth-related effects in the neonate and adult myocardium. However, very little is known regarding the regulation of the cardiac renin-angiotensin system (RAS) and the role of Ang II receptors at any developmental stage. Enhanced expression of RAS during fetal and neonatal development suggests that locally produced Ang II exerts autocrine and paracrine influences on cardiogenesis and cardiac growth in these stages of development. Utilization of transgenic models and specific nonpeptide Ang II receptor antagonists will be useful in determining the roles of AT1 and AT2 receptors, respectively, in the regulation of the cardiac RAS, myocardial growth, and apoptosis in the developing rat heart. These studies may provide a better understanding of the effects of Ang II receptors on cellular and molecular aspects of cardiac development and thus lead to improved therapeutic interventions for cardiovascular disease.

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  1. Weis Center for Research, Geisinger Clinic, Danville, PA, USA

    David E. Dostal, Rachel A. Hunt, Chris E. Kule & Kenneth M. Baker

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.) (Distinguished Professor and Director MRC Group in Experimental Cardiology), Peter Zahradka Ph.D. (Associate Professor), Ian M. C. Dixon Ph.D. (Assistant Professor) & Robert E. Beamish M.D. (Professor Emeritus) (Distinguished Professor and Director MRC Group in Experimental Cardiology),  (Associate Professor),  (Assistant Professor) &  (Professor Emeritus)

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Dostal, D.E., Hunt, R.A., Kule, C.E., Baker, K.M. (1998). Developmental Regulatlon of the Cardiac Renin-Angiotensin System: Expression and Associatlon With Growth and Apoptosis. In: Dhalla, N.S., Zahradka, P., Dixon, I.M.C., Beamish, R.E. (eds) Angiotensin II Receptor Blockade Physiological and Clinical Implications. Progress in Experimental Cardiology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5743-2_30

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