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Lysosomal Metabolism of Glycoconjugates

  • Chapter
Biology of the Lysosome

Part of the book series: Subcellular Biochemistry ((SCBI,volume 27))

Abstract

A variety of intracellular and extracellular glycoconjugates are degraded in the lysosomes of animal cells. The main groups are glycosaminoglycans, glycolipids, and glycoproteins. A portion of the cellular glycogen is also turned over in the lysosomes as a result of autophagy of cytoplasmic glycogen. The importance of the lysosomal catabolism of glycoconjugates for the normal functioning of cells and tissues is dramatically illustrated by the severe and often fatal lysosomal storage diseases that result from a genetic defect in the lysosomal catabolism of glycoconjugates. Under certain circumstances exogenous carbohydrate-containing material may be delivered to the lysosomes. This material is catabolized if the glycosidic linkages are susceptible to hydrolysis by the endogenous glycosidases.

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    Bryan G. Winchester

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Winchester, B.G. (1996). Lysosomal Metabolism of Glycoconjugates. In: Lloyd, J.B., Mason, R.W. (eds) Biology of the Lysosome. Subcellular Biochemistry, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5833-0_7

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