Abstract
Cytokines are required for B-cell proliferation and differentiation and additionally, direct Ig isotype switching. Interleukin-4 causes both murine and human B cells to undergo isotype switching to IgE synthesis; IL-4 also induces IgGl and IgG4 production by murine and human B cells, respectively. More recently IL-13 has been shown to induce Ig isotype switching to IgE and IgG4 humans. Interferon-γ (IFN-γ) is an important regulator of IgE production; it antagonizes IL-4 directed Ig isotype switching to IgE in both murine and human B cells (1–4). Additionally, IFN-γ inhibits IL-13 driven IgE synthesis by human B cells (5). In vitro, IFN-γ selectively inhibits the proliferation of TH2 cells and favors the differentiation of precursor TH0 cells into cells with a TH1 phenotype (6).
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Lack, G., Gelfand, E.W. (1996). The Role of Nebulized IFN-γ in the Modulation of Allergic Responses. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_3
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DOI: https://doi.org/10.1007/978-1-4615-5855-2_3
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