Abstract
The signaling effects of the vitamin A derivative retinoic acid are mediated by the retinoic acid receptor family (Kastner et al., 1994; Mangelsdorf et al., 1994). Recent studies on mice carrying retinoic acid receptor mutations have demonstrated that retinoic acid is essential for development of several embryonic tissues including the craniofacial region, eye, heart, and other organs (Lohnes et al., 1994; Mendelsohn et al., 1994). However, little is known about the enzymatic mechanism involved in the correct spatial and temporal regulation of retinoic acid synthesis from retinol (vitamin A) during embryonic development.
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References
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Duester, G., Deltour, L., Ang, H.L. (1996). Evidence that Class IV Alcohol Dehydrogenase May Function in Embryonic Retinoic Acid Synthesis. In: Weiner, H., Lindahl, R., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 6. Advances in Experimental Medicine and Biology, vol 414. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5871-2_41
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DOI: https://doi.org/10.1007/978-1-4615-5871-2_41
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