Abstract
1H MRS offers an interesting new noninvasive tool with which to monitor some limited aspects of brain chemistry in man [1]. The application of the method to the elucidation of HE has, in addition to the hoped for ability to demonstrate the central role of glutamine (Gln), provided two new insights into the disease. The first is the possible role of cerebral choline-containing compounds (Cho). This might have been anticipated from the role of liver in glycerophosphate and lipid biosynthesis. The second observation was without precedent and still awaits an explanation: This is the significant occurrence of cerebral myo-inositol (mI) depletion [2].
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Kanamori, K., Bluml, S., Ross, B. (1997). Magnetic Resonance Spectroscopy in the Study of Hyperammonemia and Hepatic Encephalopathy. In: Felipo, V., GrisolÃa, S. (eds) Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy. Advances in Experimental Medicine and Biology, vol 420. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5945-0_12
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