Abstract
A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of α-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kvß1.2, modifies intrinsic α-subunit C-type inactivation. N-type inactivation and open channel block have been proposed to increase the rate of development of C-type inactivation. We demonstrate here that Kvß1.2 has kinetic properties which are consistent with rapid open channel block.
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Rasmusson, R.L., Wang, S., Castellino, R.C., Morales, M.J., Strauss, H.C. (1997). The Beta Subunit, Kvβ1.2, Acts as a Rapid Open Channel Blocker of NH2-Terminal Deleted Kv1.4 α-Subunits. In: Sideman, S., Beyar, R. (eds) Analytical and Quantitative Cardiology. Advances in Experimental Medicine and Biology, vol 430. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5959-7_3
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DOI: https://doi.org/10.1007/978-1-4615-5959-7_3
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