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Prognostic factors in surgical resection for hepatocellular carcinoma

  • Chapter
Surgical Oncology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 90))

Abstract

Although a variety of new treatment modalities for hepatocellular carcinoma (HCC) have been explored in the past few years, the fact remains that surgical resection provides the only chance for long-term survival in this aggressive disease. Five-year survival rates after curative surgery average 18-36%. In general, a resectable tumor must be (1) confined to the liver (absence of vascular invasion or distant metastases) and (2) entirely encompassed by local excision with an adequate margin. In order to be a candidate for resection, the patient must also have adequate liver reserve. Only 10-15% of patients with primary liver cancer meet these requirements. Unfortunately, the majority of these patients develop recurrence and do not benefit from further resection.

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References

  1. Chen MF, Hwang TLC, Jenny YY, Wang CS. Influence of age on results of resection of hepatocellular carcinoma. Eur J Surg 157: 591–593, 1991.

    PubMed  CAS  Google Scholar 

  2. Nagasue N, Chang YC, Takemoto Y, Taniura H, Kohno H, Nakamura T. Liver resection in the aged (seventy years or older) with hepatocellular carcinoma. Surgery 113: 148–154, 1993.

    PubMed  CAS  Google Scholar 

  3. Takenaka K, Shimada M, Higashi H, Adachi E, Nishizaki T, Yanaga K, Matsumata T, Ikeda T, Sugimachi K. Liver resection for hepatocellular carcinoma in the elderly. Arch Surg 129: 846–850, 1994.

    Article  PubMed  CAS  Google Scholar 

  4. Matsumata T, Ikeda Y, Hayashi H, Kamakura T, Taketomi A, Surimachi K. The association between transfusion and cancer-free survival after curative resection for hepatocellular carcinoma. Cancer 72: 1866–1871, 1993.

    Article  PubMed  CAS  Google Scholar 

  5. Bernardi M, Grazi GL, Colantoni A, Sica G, Mazziotti A, Trevisant F, Gozzetti G, Gasbarrini G. Prognostic indicators in patients with cirrhosis and hepatocellular carcinoma undergoing surgical resection. J Surg Oncol 3(Suppl): 67–69, 1993.

    Article  CAS  Google Scholar 

  6. Nagasue N, Uchida M, Makino Y, Takemoto Y, Yamanoi A, Hayashi T, Chang YC, Kohno H, Nakamura T, Yukaya H. Incidence and factors associated with intrahepatic recurrence following resection of hepatocellular carcinoma. Gastroenterology 105: 488–494, 1993.

    Article  PubMed  CAS  Google Scholar 

  7. Demers ML, Ellis LM, Roh MS. Surgical management of hepatoma. Cancer Treat Res 69: 277–290, 1994.

    PubMed  CAS  Google Scholar 

  8. Uchida K, Jikko A, Yamato T, Kamiyama Y, Ozawa K. Relationship of glucose intolerance and indocyanine green clearance to respiratory enzyme levels in human cirrhotic liver. Am J Med Sci 290: 19–27, 1985.

    Article  PubMed  CAS  Google Scholar 

  9. Yamanaka N, Okamoto E, Oriyama T, Fujimoto J, Furukawa K, Kawamura E, Tanaka T, Tomada F. A prediction scoring system to select the surgical treament of liver cancer. Futher refinement based on 10 years of use. Ann Surg 219: 342–346, 1994.

    Article  PubMed  CAS  Google Scholar 

  10. Ishikawa A, Fukao K, Tsuji K, Osada A, Yamamoto Y, Ohtsuka M, Tanaka E. Trimethadione tolerance tests for the assessment of feasible size of hepatic resection in patients with heaptocellular carcinoma. J Gastroenterol Hepatol 8: 426–432, 1993.

    Article  PubMed  CAS  Google Scholar 

  11. Fan ST, Lai EC, Lo CM, Ng IO, Wong J. Hospital mortality of major hepatectomy for hepatocellular carcinoma associated with cirrhosis. Arch Surg 130: 198–203, 1995.

    Article  PubMed  CAS  Google Scholar 

  12. Yamanaka N, Okamoto E, Toyosaka A, Mitunobu M, Fujihara S, Kato T, fujimoto J, Oriyama T, Furukawa K, Kawamura E. Prognostic factors after hepatectomy for hepatocellular carcinomas. Cancer 65: 1104–1110, 1990.

    Article  PubMed  CAS  Google Scholar 

  13. Nagao T, Nagashima I, Inoue S, Omori Y, Kawano N, Morioka Y. Hepatic resection for minute hepatocellular carcinoma. Surg Today 22: 110–114, 1992.

    Article  PubMed  CAS  Google Scholar 

  14. Nagasue N, Kohno H, Chang YC, Taniura H, Yamanoi A, Uchida M, Kimoto T, Takemoto Y, Nakamura T, Yukaya H. Liver resection for hepatocellular carcinoma. Results of 229 consecutive patients during 11 years. Ann Surg 217: 375–384, 1993.

    Article  PubMed  CAS  Google Scholar 

  15. Nagasue N, Kohno H, Chang YC, Taniura H, Yamanoi A, Uchida M, Kimoto T, Takemoto Y, Nakamura T, Yukaya H. Liver resection for hepatocellular carcinoma. Results of 229 coansecutive patients during 11 years. Ann Surg 217: 375–384, 1993.

    Article  PubMed  CAS  Google Scholar 

  16. Okada S, Shimada K, Yamamoto J, Takayama T, Kosuge T, Yamasaki S, Sakamoto M, Hirohashi S. Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology 106: 1618–1624, 1994.

    PubMed  CAS  Google Scholar 

  17. Yamamoto J, Kosuge T, Takayama T, Shimada K, Yamasaki S, Ozaki H, Yamaguchi N, Mizuno S, Makuuchi M. Perioperative blood transfusion promotes recurrence of hepatocellular carcinoma after hepatectomy. Surgery 115: 303–309, 1994.

    PubMed  CAS  Google Scholar 

  18. Ringe B, Pichlmayr R, Wittekind C, Tusch G. Surgical treatment of hepatocellular carcinoma: Experience with liver resection and transplantation in 198 patients. World J Surg 15: 270–285, 1991.

    Article  PubMed  CAS  Google Scholar 

  19. Soreide O, Czerniak A, Bradpiece H, Bloom S, Blumgart L. Characteristics of fibrolamellar hepatocellular carcinoma. A study of nine cases and review of the literature. Am J Surgery 151: 518–523, 1986.

    Article  CAS  Google Scholar 

  20. Ringe B, Wittekind C, Weimann A, Tusch G, Pichimayr R. Results of hepatic resection and transplantation for fibrolamellar carcinoma. Surg Gynecol Obstet 175: 299–305, 1992.

    PubMed  CAS  Google Scholar 

  21. Makuuchi M, Kosuge T, Takayamas T, Yamazaki S, Kakazu T, Miyagawa S, Kawasaki S. Surgery for small liver cancers. Semin Surg Oncol 9: 298–304, 1993.

    Article  PubMed  CAS  Google Scholar 

  22. Jwo SC, Chiu JH, Chau GY, Loong CC, Lui WY. Risk factors linked to tumor recurrence of human hepatocellular carcinoma after hepatic resection. Hepatology 16: 1367–1371, 1992.

    Article  PubMed  CAS  Google Scholar 

  23. Suenaga M, Nakao A, Harada A, Nonami T, Okada Y, Surgiura H, Uehara S, Takagi H. Hepatic resection for hepatocellular carcinoma. World J Surg 16: 97–105, 1992.

    Article  PubMed  CAS  Google Scholar 

  24. Sugioka A, Tsuzuki T, Kanai T. Postresection prognosis of patients with hepatocellular carcinoma. Surgery 113: 612–618, 1993.

    PubMed  CAS  Google Scholar 

  25. Belghiti J, Panis Y, Farges O, Benhamou JP, Fekete F. Intrahepatic recurrence after resection of hepatocellular carcinoma complicating cirrhosis. Ann Surg 214: 114, 1991.

    Article  PubMed  CAS  Google Scholar 

  26. Vauthey JN, Kimstra D, Franceschi D, Tao Y, Fortner J, Blumgart L, Brennan M. Factors affecting long-term outcome after hepatic resection for hepatocellular carcinoma. Am J Surg 169: 28–34; discussion pp 34-35, 1995.

    Article  PubMed  CAS  Google Scholar 

  27. Zhou X, Yu Y, Tang Z. Advances in surgery for hepatocellular carcinoma. Asian J Surg 17: 34–39, 1994.

    Google Scholar 

  28. Lai E, Ng I, You K, Choi T, Fan S, Mok F, Wong J. Hepatectomy for large hepatocellular carcinoma: The optimal resection margin. World J Surg 15: 141–145, 1991.

    Article  PubMed  CAS  Google Scholar 

  29. Lai EC, You KT, Ng IO, Shek TW. The pathological basis of resection margin for hepatocellular carcinoma. World J Surg 17: 786–791, 1993.

    Article  PubMed  CAS  Google Scholar 

  30. Zhou X, Tang A, Yu Y, Ma Z, Yang B, Lu J, Lin Z, Wang J. Solitary minute hepatocellular carcinoma. A study of 14 patients. Cancer 67: 2855–2858, 1991.

    Article  PubMed  CAS  Google Scholar 

  31. Shirabe K, Kanematsu T, Matsumata T, Adachi T, Adachi E, Akazawa K, Sugimachi K. Factors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: Univariate and multivariate analyses. Hepatology 14: 802–805, 1991.

    Article  PubMed  CAS  Google Scholar 

  32. Kawarada Y, Ito F, Sakurai H, Tanigawa K, Iwata M, Imai T, Yokoi H, Noguchi T, Mizumoto R. Surgical treatment of heaptocellular carcinoma. Cancer Chemother Pharmacol 33(Suppl): S12–S17, 1994.

    Article  PubMed  Google Scholar 

  33. Zhou XD, Tang ZY, Yu YQ, Ma ZC, Yang BH, Lu JZ, Lin ZY, Tang CL. Prognostic factors or primary liver cancer: Report of 83 patients surviving 5 years of more compared with 811 patients surviving less than 5 years. J Exp Clin Cancer Res 10: 81, 1991.

    Google Scholar 

  34. Bruix J, Cirerai I, Calvet X, Fuster J, Bru C, Ayuso C, Vilana R, Boix L, Visa J, Rodes J. Surgical resection and survival in Western patients with hepatocellular carcinoma. J Hepatol 15: 350–355, 1992.

    Article  PubMed  CAS  Google Scholar 

  35. Torii A, Nonami T, Harada A, Yasui M, Nakao A, Takagi H. Extent of hepatic resection as a prognostic factor for small, solitary hepatocellular carcinomas. J Surg Oncol 54: 13–17, 1993.

    Article  PubMed  CAS  Google Scholar 

  36. Shimada M, Matsumata T, Maeda T, Yanaga K, Taketomi A, Sugimachi K. Characteristics of hepatocellular carcinoma originating in the caudate lobe. Hepatology 19: 911–915, 1994.

    Article  PubMed  CAS  Google Scholar 

  37. Wu CC, Hwang CJ, Yang MD, Liu TJ. Preliminary results of hepatic for centrally located large hepatocellular carcinoma. Austral N Z Surgery 63: 525–529, 1993.

    Article  CAS  Google Scholar 

  38. Zhou X, Yu Y, Tang Z, Ma Z. Results of liver resection for primary liver cancer. J Hep Bil Cancer Surg 2: 118–122, 1994.

    Article  Google Scholar 

  39. LaBerge L, Laing F, Federle M, Jeffrey R, Lim R. Hepatocellular carcinoma: Assessment of resectability by computed tomography and ultrasound. Radiology 152: 485–490, 1984.

    PubMed  CAS  Google Scholar 

  40. Izumi R, Shimizu K, Ii T, Yagi M, Matsui O, Nonomura A, Miyazaki I. Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. Gastroenterology 106: 720–727, 1994.

    PubMed  CAS  Google Scholar 

  41. Kosuge T, Makuuchi M, Takayama T, Yamamoto J, Shimada K, Yamasaki S. Long-term results after resection of hepatocellular carcinoma: Experience of 480 cases. Hepatogastroenterology 40: 328–332, 1993.

    PubMed  CAS  Google Scholar 

  42. Kawasaki S, Makuuchi M, Miyagawa S, Kakazu T, Hayashi K, Kasai H, Miwa S, Hui AM, Nishimaki K. Results of hepatic resection for hepatocellular carcinoma. World J Surg 19: 31–34, 1995.

    Article  PubMed  CAS  Google Scholar 

  43. Ozawa K, Takayasu T, Kumada K, Yamaoka Y, Tanaka K, Kobayashi N, Inamoto T, Shimahara Y, Mori K, Honda K, Asonuma K. Experience with 225 hepatic resection for hepatocellular carcinoma over a 4-year period. Am J Surg 161: 677, 1991.

    Article  PubMed  CAS  Google Scholar 

  44. Harada T, Shigemura T, Kodama S, Higuchi T, Ikeda S, Okazaki M. Hepatic resection is not enough for hepatcellular carcinoma. A follow-up study of 92 patients. J Clin Gastroenterol 14: 245–250, 1992.

    Article  PubMed  CAS  Google Scholar 

  45. HaradaT, Kodama S, Matsuo K, Higuchi T, Nagai T, Ikeda S, Okazaki M. Surgical management of large hepatocellular carcinomas: Criteria for curative hepatectomy. Int Surg 78: 284–287, 1993.

    PubMed  CAS  Google Scholar 

  46. Jeng KS, Chen BF, Lin HJ. En bloc resection for extensive hepatocellular carcinoma: Is it advisable? World J Surg 18: 834–839, 1994.

    Article  PubMed  CAS  Google Scholar 

  47. Lau WY, Leung KL, Leung TW, Liew CT. Resection of hepatocellular carcinoma with diaphragmatic invasion. Br J Surg 82: 264–266, 1995.

    Article  PubMed  CAS  Google Scholar 

  48. Sasaki Y, Imaoka S, Masutani S, Ohashi I, Ishikawa O, Koyama H, Iwanaga T. Influence of coexisting cirrhosis on long-term pognosis after surgery in patients with hepatocellular carcinoma. Surgery 112: 515–521, 1992.

    PubMed  CAS  Google Scholar 

  49. Chou FF, Sheen-Chen SM, Chen CL, Chen YS, Chen MJ. Prognostic factors after hepatectomy for hepatocellular carcinoma. Hepatogastroenterology 41: 419–423, 1994.

    PubMed  CAS  Google Scholar 

  50. Capussotti L, Borgonovo G, Bouzari H, Smudge C, Grange D, Franc D. Results of major hepatectomy for large primary liver cancer in patients with cirrhosis. Br J Surg 81: 427–431, 1994.

    Article  PubMed  CAS  Google Scholar 

  51. Takeda S, Nagafuchi Y, Tashiro H, Abe Y, Fukushige H, Komori H, Okamoto K, Ohsato K, Haratake J. Antihepatitis C virus status in hepatocellular carcinoma and the influence on clinicopathological findings and operative results. Br J Surg 79: 1195–1198, 1992.

    Article  PubMed  CAS  Google Scholar 

  52. Tarao K, Ohkawa S, Shimizu A, et al. DNA synthesis activities of hepatocytes from noncan-cerous cirrhotic tissue and of hepatocellular carcinoma (HCC) cells from cancerous tissue can predict the survival of hepatectomized patients with HCC. Cancer 71: 3859–3863, 1993.

    Article  PubMed  CAS  Google Scholar 

  53. Chiu JH, Wu LH, Kao HL, Chang HM, Tsay SH, Loong CC, Chau GY, Lui WY. Can determination of the proliferative capacity of the nontumor portion predict the risk of tumor recurrence in the liver remnant after resection of human hepatocellular carcinoma? Hepatology 18: 96–102, 1993. [published erratum appears in Hepatology 18: 1292, 1993.]

    Article  PubMed  CAS  Google Scholar 

  54. Adachi E, Maeda T, Matsumata T, Shirabe K, Kinukawa N, Sugimachi K, Tsuneyoshi M. Risk factors for interhepatic recurrence in human small hepatocellular carcinoma. Gastroenterology 108: 768–775, 1995.

    Article  PubMed  CAS  Google Scholar 

  55. Chen MF, Hwang TL, Jeng LB. Hepatic resection for 28 patients with small hepatocellular carcinoma. Int Surg 77: 72–76, 1992.

    PubMed  CAS  Google Scholar 

  56. Chen MF, Hwang TL, Jeng LB, Wang CS, Jan YY, Chen SC. Postoperative recurrence of hepatocellular carcinoma. Two hundred five consecutive patients who underwent hepatic resection in 15 years. Arch Surg 129: 738–742, 1994.

    Article  PubMed  CAS  Google Scholar 

  57. Kawai Y, Takeshige K, Nunome M, Kuroda H, Suzuki H, Banno K, Koide T, Kobayashi H, Owa Y, Koike A. Prognosis after hepatic resection in patients with hepatocellular carcinoma, estimated on the basis of the morphometric indices. Cancer Chemother Pharmacol 33(Suppl): S24–S28, 1994.

    Article  PubMed  Google Scholar 

  58. Kim ST, Kim KP. Hepatic resections for primary liver cancer. Cancer Chemother Pharmacol 33(Suppl): S18–S23, 1994.

    Article  PubMed  Google Scholar 

  59. Lai EC, Fan ST, Lo CM, Chu KM, Liu CL, Wong J. Hepatic resection for hepatocellular carcinoma. An audit of 343 patients. Ann Surg 221: 291–298, 1995.

    Article  PubMed  CAS  Google Scholar 

  60. Gouillat C, Manganas D, Berard P. Ultrasonically guided hepatic tumorectomy. J Am Coll Surg 180: 616–618, 1995.

    PubMed  CAS  Google Scholar 

  61. Lau WY, Leung KL, Lee TW, Li AK. Ultrasonography during liver resection for hepatocellular carcinoma. Br J Surg 80: 493–494, 1993.

    Article  PubMed  CAS  Google Scholar 

  62. Lygidakis NJ, Makuuchi M. Clinical application of preoperative ultrasonography in liver surgery. Hepatogastroenterology, 39: 232–236, 1992.

    PubMed  CAS  Google Scholar 

  63. Wu CC, Yang MD, Liu TJ. Improvements in hepatocellular carcinoma resection by intraoperative ultrasonography and intermittent hepatic inflow blood occusion. Jpn J Clin Oncol 22: 107–112, 1992.

    PubMed  CAS  Google Scholar 

  64. Ravikumar TS, Buenaventura S, Salem RR, D’Andrea B. Intraoperative ultrasonagraphy of liver: Detection of occult liver tumors and treatment by cryosurgery. Cancer Detect Prev 18: 131–138, 1994.

    PubMed  CAS  Google Scholar 

  65. Masutani S, Sasaki Y, Imaoka S, et al. The prognostic significance of surgical margin in liver resection of patients with hepatocellular carcinoma. Arch Surg 129: 1025–1030, 1994.

    Article  PubMed  CAS  Google Scholar 

  66. Ouchi K, Matsubara S, Fukuhara K, Tominaga T, Matsuno S. Recurrence of hepatocellular carcinoma in the liver remnant after hepatic resection. Am J Sur 166: 270, 1993.

    Article  CAS  Google Scholar 

  67. Hamazaki K, Mimura H, Orita K, Lygidakis NJ. Surgical treatment for hepatocellular carcinoma (HCC) 3 cm or less than 3 cm in diameter. Hepatogastroenterology 39: 574–576, 1992.

    PubMed  CAS  Google Scholar 

  68. Tjandra JJ, Fan ST, Wong J. Peri-operative mortality in hepatic resection. Austal N Z J Surg 61: 201–206, 1991.

    Article  CAS  Google Scholar 

  69. Huguet C, Gavelli A, Chieco PA, Bona S, Harb J, Joseph JM, Jobard J, Garmaglia M, Lasserre M. Liver ischemia for hepatic reseaction: Where is the limit? Surgery 111: 251–259, 1992.

    PubMed  CAS  Google Scholar 

  70. Kajikawa M, Nonami T, Kurokawa T, Hashimoto S, Harada A, Nakao A, Takagi H. Autolo-gous blood transfusion for hepatectomy in patients with cirrhosis and hepatocellur carcinoma: Use of recombinant human erythropoietin. Surgery 115: 727–734, 1994.

    PubMed  CAS  Google Scholar 

  71. Bismuth H, Chiche L, Castaing D. Surgical treatment of hepatocellular carcinomas in noncirrhotic liver: Experience with 68 liver resections. World J Surg 19: 35–41, 1995.

    Article  PubMed  CAS  Google Scholar 

  72. Kakazu T, Makuuchi M, Kawasaki S, Miyagawa S, Hashikura Y, Kosuge T, Takayama T, Yamamoto J. Repeat hepatic resection for recurrent hepatocellular carcinoma. Hepatogastroenterology 40: 337–341, 1993.

    PubMed  CAS  Google Scholar 

  73. Nakajima Y, Ohmura T, Kimura J, Shimamura T, Misawa K, Matsushita M, Sato N, Une Y, Uchino J. Role of surgical treatment for recurrenct hepatocellular carcinoma after hepatic resection. World J Surg 17: 792–795, 1993.

    Article  PubMed  CAS  Google Scholar 

  74. Shimada M, Matsumata T, Taketomi A, Yamamoto K, Itasaka H, Sugimachi K. Repeat hepatectomy for recurrent hepatocellular carcinoma. Surgery 115: 703–706, 1994.

    PubMed  CAS  Google Scholar 

  75. Suenaga M, Surgiura H, Kokuba S, Kurumiya T. Repeated hepatic resection of recurrent hepatocellular carcinoma in eighteen cases. Sugery 115: 452–457, 1994.

    CAS  Google Scholar 

  76. Zhou X, Tang Z, Yu Y, Yang B, Lin Z, Lu J, Ma Z, Tang C. Long-term survivors after resection for primary liver cancer. Clinical analysis of 19 patients surviving more than ten years. Cancer 63: 2201–2206, 1989.

    Article  PubMed  CAS  Google Scholar 

  77. Lo CM, Lai EC, Fan ST, Choi TK, Wong J. Resection for extrahepatic recurrence of hepatocellular carcinoma. Br J Surg 81: 1019–1021, 1994.

    Article  PubMed  CAS  Google Scholar 

  78. McPeake JR, O’Grady JG, Zaman S, Portmann B, Wight DG, Tan KC. Calne RY, Williams R. Liver transplantation for primary hepatocellular carcinoma: Tumor size and number determine outcome. J Hepatol 18: 226–234, 1993.

    Article  PubMed  CAS  Google Scholar 

  79. Bismuth H, Chiche L, Adam R, Castaing D, Diamond T, Dennison A. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg 218: 145–151, 1993.

    Article  PubMed  CAS  Google Scholar 

  80. Bismuth H, Chiche L. Comparison of hepatic resection and transplantation in the treatment of liver cancer. Semin Surg Oncol 9: 341–345, 1993.

    Article  PubMed  CAS  Google Scholar 

  81. Caine R, Yamanoi A, Oura S, Kawamura M. Liver transplantation for hepatocarcinoma. Surg Today 23: 1–3, 1993.

    Article  Google Scholar 

  82. Venook AP. Treatment of hepatocellular carcinoma: Too many options? J Clin Oncol 12: 1323–1334, 1994.

    PubMed  CAS  Google Scholar 

  83. Lygidakis NJ, Konstantinidou T, Pothoulakis J. Pre-and post-operative adjuvant targeting locoregional chemotherapy combined with locoregional targeting immunostimulation and surgical resection for hepatocellular carcinoma. A new promising alternative. Anticancer Res 14: 1351–1355, 1994.

    PubMed  CAS  Google Scholar 

  84. Gururangan S, O’Meara A, MacMahon C, Guiney EJ, O’Donnell B, Fitzgerald RJ, Breatnach F. Primary hepatic tumors in children: A 26-year review J Surg Oncol 50: 30–36, 1992.

    Article  PubMed  CAS  Google Scholar 

  85. Harada A, Nonami T, Kishimoto W, Nakao A, Takagi H. Results of hepatic resection and postoperative arterial chemotherapy for hepatocellular carcinoma. Cancer Chemother Pharmacol 31(Suppl): S35–S37, 1992.

    Article  PubMed  Google Scholar 

  86. Tsuzuki T, Sugioka A, Ueda M, Iida S, Kanai T, Yoshii H, Nakayau K. Hepatic resection for hepatocellular carcinoma. Surgery 107: 511–520, 1990.

    PubMed  CAS  Google Scholar 

  87. Nagorney DM, Adson MA, Weiland LH. Fibrolamellar hepatoma. Am J Surgery 149: 113–119, 1985.

    Article  CAS  Google Scholar 

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Roseman, B.J., Roh, M.S. (1997). Prognostic factors in surgical resection for hepatocellular carcinoma. In: Pollock, R.E. (eds) Surgical Oncology. Cancer Treatment and Research, vol 90. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6165-1_17

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