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Angiogenesis and Collateral Formation

  • Chapter
Gene Transfer in the Cardiovascular System

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 189))

Abstract

Angiogenic cytokines constitute a potentially novel form of therapy for patients with cardiovascular disease. The feasibility of using recombinant formulations of angiogenic growth factors to expedite and/or augment collateral artery development in animal models of myocardial and hindlimb ischemia — “therapeutic angiogenesis” — has now been well established. These studies have suggested that two angiogenic growth factors in particular, basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), are sufficiently potent to merit further investigation. More recently, experiments performed in our laboratory have indicated that in the case of VEGF, a secreted protein, similar results may be achieved by percutaneous arterial gene transfer. Further laboratory and clinical studies may yield promising insights into the fundamental basis for native as well as therapeutic angiogenesis, and at the same time more explicitly define the manner in which therapeutic angiogenesis may be successfully incorporated into clinical practice.

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Authors and Affiliations

  1. Departments of Medicine (Cardiology) and Biomedical Research, St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, MA, USA

    Jeffrey M. Isner M.D.

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  1. Jeffrey M. Isner M.D.
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Editors and Affiliations

  1. Krannert Institute of Cardiology, Indiana University Medical Center, Indianapolis, Indiana, USA

    Keith L. March M.D., Ph.D.

  2. R. L. Roudebush VA Medical Center, Indianapolis, Indiana, USA

    Keith L. March M.D., Ph.D.

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Isner, J.M. (1997). Angiogenesis and Collateral Formation. In: March, K.L. (eds) Gene Transfer in the Cardiovascular System. Developments in Cardiovascular Medicine, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6277-1_14

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  • DOI: https://doi.org/10.1007/978-1-4615-6277-1_14

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