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Comparative Effects of Ischemia and Hypoxia on Ventricular Relaxation in Isolated Perfused Hearts

  • Chapter
Diastolic Relaxation of the Heart

Abstract

Many experimental studies of left ventricular diastolic properties have utilized isolated perfused hearts subjected to either global ischemia or hypoxia. The isolated perfused heart model (see Figure 18-1) has several advantages. The pericardium is removed and the right ventricle is vented; thus, any pericardial or right ventricular interaction effect on left ventricular diastolic relaxation [1–4] is eliminated. Because the imposed ischemic or hypoxic condition is globally distributed throughout the myocardium, regional or segmental differences in contractility are eliminated, thus negating the effects on relaxation of “strong and weak segments in series” [6–7]. For these reasons, the isolated perfused heart model assesses the diastolic properties of the left ventricular chamber consisting of myocytes, connective tissue elements, interstitial fluid, and coronary vasculature.

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Authors
  1. Carl S. Apstein
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  2. Laura F. Wexler
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  3. W. Mark Vogel
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  4. Ellen O. Weinberg
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  5. Joanne S. Ingwall
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Editor information

Editors and Affiliations

  1. Harvard Medical School, Cardiovascular Division, Beth Israel Hospital, Boston, Massachusetts, USA

    William Grossman M.D. (Herman Dana Professor of Medicine, Chief) (Herman Dana Professor of Medicine, Chief)

  2. Harvard Medical School, Hemodynamic Research Laboratory, Beth Israel Hospital, Boston, Massachusetts, USA

    Beverly H. Lorell M.D. (Assistant Professor of Medicine, Co-Director) (Assistant Professor of Medicine, Co-Director)

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© 1987 Martinus Nijhoff Publishing

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Apstein, C.S., Wexler, L.F., Vogel, W.M., Weinberg, E.O., Ingwall, J.S. (1987). Comparative Effects of Ischemia and Hypoxia on Ventricular Relaxation in Isolated Perfused Hearts. In: Grossman, W., Lorell, B.H. (eds) Diastolic Relaxation of the Heart. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6832-2_18

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  • DOI: https://doi.org/10.1007/978-1-4615-6832-2_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6834-6

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