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The Deoxyglucose Method for the Measurement of Local Glucose Utilization and the Metabolic Mapping of Functional Neural Pathways in the Central Nervous System

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Research Methods in Neurochemistry

Abstract

The brain is a complex, heterogeneous organ composed of many anatomic and functional components with markedly different levels of functional activity that vary independently with time and function. Other tissues are generally far more homogeneous, with most of their cells functioning similarly and synchronously in response to a common stimulus or regulatory influence. The central nervous system, however, consists of innumerable subunits, each integrated into its own set of functional pathways and networks and subserving only one or a few of the many activities in which the nervous system participates. Understanding how the nervous system functions requires knowledge not only of the mechanisms of excitation and inhibition but even more of their precise localization in the nervous system and the relationships of neural subunits to specific functions.

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Author information

Authors and Affiliations

  1. Laboratory of Cerebral Metabolism, Public Health Service, Department of Health and Human Services, National Institute of Mental Health, Bethesda, Maryland, 20205, USA

    Louis Sokoloff, Charles Kennedy & Carolyn B. Smith

Authors
  1. Louis Sokoloff
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  2. Charles Kennedy
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  3. Carolyn B. Smith
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Editor information

Editors and Affiliations

  1. Center for Neurochemistry, Rockland Research Institute, Wards Island, New York, New York, USA

    Neville Marks

  2. Department of Biochemistry, Institute of Psychiatry, University of London, London, Great Britain

    Richard Rodnight

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© 1985 Plenum Press, New York

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Sokoloff, L., Kennedy, C., Smith, C.B. (1985). The Deoxyglucose Method for the Measurement of Local Glucose Utilization and the Metabolic Mapping of Functional Neural Pathways in the Central Nervous System. In: Marks, N., Rodnight, R. (eds) Research Methods in Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7760-7_3

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  • DOI: https://doi.org/10.1007/978-1-4615-7760-7_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7762-1

  • Online ISBN: 978-1-4615-7760-7

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