Abstract
The presence in hypothalamic tissue of extractable substances, called releasing factors or hormones, which can either stimulate or repress the release of hormones from the adenohypophysis is well established. Moreover, the activities of these hypothalamic substances have been demonstrated under in vivo as well as in vitro conditions. At least three of these factors, luteinizing hormone releasing hormone (LHRH), thyrotropin releasing hormone (TRH), and somatostatin, have been isolated in pure form and found on analysis to be small peptides (1–4). Their amino acid sequences have been determined, and each has been synthesized. The availability of these synthetic compounds has made it possible to develop sensitive immunoassays for each peptide. As a consequence, it is now feasible to address critically the issue of secretion of these hypothalamic hormones and to test with rigor the question of whether these peptides have significant roles in the physiological regulation of the adenohypophysis.
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Porter, J.C. et al. (1977). Release of Hypothalamic Hormones under in Vivo and in Vitro Conditions. In: Porter, J.C. (eds) Hypothalamic Peptide Hormones and Pituitary Regulation. Advances in Experimental Medicine and Biology, vol 87. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8849-8_9
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DOI: https://doi.org/10.1007/978-1-4615-8849-8_9
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