Abstract
After the divergent and inconclusive effects obtained in treatment of female sterility with gonadotropin extracts obtained from animal pituitaries or from pregnant mare serum (PMS), our group, which was involved in the preparation of chorionic gonadotropin (HCG), started in 1949 to study the possibility of the preparation of human menopausal gonadotropin (HMG) suitable for treatment in humans. In the same year we published our first paper (1) on the preparation of HMG suitable for clinical investigation and Pergonal became available to physicians in Italy in 1950.
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References
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Donini, P. (1970). Preparations and Biological Characteristics of HMG Preparations Used Clinically. In: Rosemberg, E., Paulsen, C.A. (eds) The Human Testis. Advances in Experimental Medicine and Biology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9008-8_21
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DOI: https://doi.org/10.1007/978-1-4615-9008-8_21
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