Abstract
Evidence from clinical and experimental analyses has revealed deficiency of immune function with age in some individuals or animals and not in others (1–6). The immune deficiencies observed during aging are similar to those produced or accelerated by neonatal thymectomy (2–8). Cell mediated immunity deteriorates spontaneously at an earlier age in autoimmune susceptible strains than in autoimmune resistant strains of mice (2,5,8,9). We have suggested that there is a progressive quantitative loss of post-thymic cells during aging (2–4, 7).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Walford, R.L.: The Immunologic Theory of Aging. Munksgaard, Copenhagen, 1969.
Yunis, E.J., Fernandes, G., Stutman, O., Teague, P.O. and Good, R.A.: In: Tolerance, Immunity and Molecular Aging, (Sigel and Good, eds.), Chp. 4, by Charles C. Thomas, publisher, Illinois, 1972.
Yunis, E.J., Stutman, O., and Good, R.A.: Nat.Acad.Sci. p. 109, 1971.
Yunis, E.J., Fernandes, G., and Stutman, O.: Amer.J.Clin. Path. 56: 280, 1971.
Teague, P.O., Yunis, E.J., Rodey, G., Fish, A.J., Stutman, O., and Good, R.A.: Lab.Invest. 22: 121, 1970.
Teague, P.O., Friou, G.J., Yunis, E.J. and Good, R.A.: In: Tolerance, Immunity and Molecular Aging, (Sige1 and Good, eds.), Chp.3, by Charles C. Thomas, publisher, Illinois, 1972.
Yunis, E.J., Stutman, O., and Good, R.A.: Ann.N.Y.Acad.Sci. 83: 205, 1971.
Rodey, G., Good, R.A., and Yunis, E.J.: Clin.Exp.Immunol. 9: 305, 1971.
Stutman, O., Yunis, E.J., and Good, R.A.: Proc. Soc. Exp. Biol. Med. 127: 1204, 1968.
Inbred Strains of Mice, No.6, July 1969, Jackson Laboratory,
Stutman, O., Yunis, E.J., and Good, R.A.: J. Nat. Cancer Inst, 41: 1431, 1968.
Stutman, O.: J. Immunol. In press.
Stutman, O., Yunis, E.J. and Good, R.A.: J.Exp.Med. 135: 339, 1972.
Yunis, E.J., Hong, R., Grewe, M.A., Martinez, C., Cornelius, E., and Good, R.A.: J.Exp.Med. 125: 947, 1967.
Yunis, E.J., Teague, P.O., Stutman, O. and Good, R.A.: Lab. Invest. 20: 46, 1969.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Plenum Press, New York
About this chapter
Cite this chapter
Yunis, E.J., Fernandes, G., Smith, J., Stutman, O., Good, R.A. (1973). Involution of the Thymus Dependent Lymphoid System. In: Janković, B.D., Isaković, K. (eds) Microenvironmental Aspects of Immunity. Advances in Experimental Medicine and Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9017-0_44
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9017-0_44
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9019-4
Online ISBN: 978-1-4615-9017-0
eBook Packages: Springer Book Archive