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Idiotypes, T-Cell Receptors, and T-B Cooperation

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Contemporary Topics in Immunobiology

Part of the book series: Contemporary Topics in Immunobiology ((CTI,volume 9))

Abstract

Immune responses in mammals, such as the production of antibody or the rejection of foreign (i.e., non-self) tissue grafts, are the result of complex interactions among a variety of different cell types. The hallmarks of the mammalian immune system — specificity, inducibility, memory, and regulation — have been conclusively shown to be associated with lymphocytes (Gowans, 1970). The division of lymphocytes into two major classes, known as T cells (thymus-derived lymphocytes) and B cells (bone-marrow-derived, thymus-independent lymphocytes), has led to an appreciation of the central role of the T cells in virtually all immune responses. This chapter will explore the genetic and environmental influences that govern T-cell specificity and behavior, as well as some interactions by which T cells regulate immune responses.

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Abbreviations

B:

Bone-marrow-derived, thymus-independent

BUdR:

5-bromodeoxyuridine

CH :

Heavy-chain constant region

DNP:

2,4-dinitrophenyl

Ig:

Immunoglobulin

MHC:

Major histocompatibility complex

OVA:

Egg albumin

SHI:

Pneumococcal Polysaccharide

T:

Thymus-derived

TNP:

2,4,6-trinitrophenyl

VH:

Heavy-chain variable region

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Authors and Affiliations

  1. Department of Pathology, Immunology Division, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Charles A. Janeway Jr. (Investigator)

  2. Howard Hughes Medical Institute, USA

    Charles A. Janeway Jr. (Investigator)

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  1. Charles A. Janeway Jr.
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Editors and Affiliations

  1. Frederick Cancer Research Center, Frederick, Maryland, USA

    John J. Marchalonis

  2. University of Rochester, Rochester, New York, USA

    Nicholas Cohen

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Janeway, C.A. (1980). Idiotypes, T-Cell Receptors, and T-B Cooperation. In: Marchalonis, J.J., Cohen, N. (eds) Contemporary Topics in Immunobiology. Contemporary Topics in Immunobiology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9131-3_7

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