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The Oxidative Metabolism of Monocytes

  • Chapter
Biochemistry and Metabolism

Abstract

The mononuclear phagocytes comprise a widely distributed and morphologically heterogeneous cell system. Originating from bone marrow stem cells, through the stages of monoblasts and promonocytes, these cells mature into monocytes which are released into the blood. After a few days in the circulation, the monocytes migrate into tissues to form the macrophages of the lungs, liver, spleen, lymphoid organs, pleural and peritoneal cavities, bones, etc. Here, a further differentiation takes place according to their specific functions in the various tissues. In general, macrophages are large cells with a high phagocytic and protein-synthesizing capacity but with a low self-replicating ability.

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Authors and Affiliations

  1. Department of Blood Cell Chemistry, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands

    D. Roos

  2. Laboratory of Clinical and Experimental Immunology, University of Amsterdam, 1006 AD, Amsterdam, The Netherlands

    A. J. M. Balm

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  1. D. Roos
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Editors and Affiliations

  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA

    Robert R. Strauss

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© 1980 Plenum Press, New York

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Roos, D., Balm, A.J.M. (1980). The Oxidative Metabolism of Monocytes. In: Sbarra, A.J., Strauss, R.R. (eds) Biochemistry and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9134-4_8

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  • DOI: https://doi.org/10.1007/978-1-4615-9134-4_8

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