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Precursor Processing and Metabolism of Parathyroid Hormone: Regulation by Calcium

  • Chapter
Proteases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 167))

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Abstract

Parathyroid hormone (PTH) raises serum calcium levels through stimulation of the tubular reabsorption of calcium and of bone resorption, and of the formation of 1,25-dihydroxycholecalciferol enhancing the intestinal absorption of calcium (for references see Fischer, 1982). Conversely, the extracellular calcium concentration is the most important regulator of the biosynthesis and secretion, and possibly of the metabolism of the hormone. Indeed, biosynthesis and secretion of PTH are stimulated by low extracellular calcium concentrations (Moran et al., 1981; Sherwood et al., 1968). Biosynthetic precursors of PTH have not been detected outside of parathyroid cells. However, proportionally higher amounts of biologically inactive PTH fragments are secreted in the face of raised extracellular calcium levels (Hanley et al., 1978; Mayer et al., 1979). The metabolism of PTH, furthermore, takes place in peripheral organs such as the liver and the kidneys (Canterbury et al., 1975; Hruska et al., 1977).

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Authors and Affiliations

  1. Research Laboratory for Calcium Metabolism, Departments of Orthopedic Surgery (Balgrist) and Medicine, University of Zurich, 8008, Zurich, Switzerland

    Jan A. Fischer

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  1. Jan A. Fischer
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  1. University of Würzburg, Würzburg, Federal Republic of Germany

    Walter H. Hörl  & August Heidland  & 

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© 1984 Plenum Press, New York

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Fischer, J.A. (1984). Precursor Processing and Metabolism of Parathyroid Hormone: Regulation by Calcium. In: Hörl, W.H., Heidland, A. (eds) Proteases. Advances in Experimental Medicine and Biology, vol 167. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9355-3_12

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  • DOI: https://doi.org/10.1007/978-1-4615-9355-3_12

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