Abstract
These two important protozoan diseases, leishmaniasis and Chagas’ disease, will be considered together not only because both are caused by species of hemoflagellates that develop intracellularly, but also because the manifestations of both depend to a great extent on the immunological reactions of the host. This is particularly true of the leishmaniases, a group of diseases caused by various species and subspecies of the genus Leishmania all transmitted by sand flies of the genera Phlebotomus, Lutzomyia, and others. All are zoonoses in the sense that a variety of mammals, wild or domesticated, such as rodents, opossums, or dogs, serve as reservoir hosts. As already discussed (Chapter 3), the most remarkable characteristic of the Leishmania is that their habitat in the vertebrate host is within the macrophage, the very cell that normally constitutes the first line of defense against invading organisms. Furthermore, they actually multiply within the phagolysosomes. Somehow they are impervious to the low pH (around 5) and the powerful hydrolases of the phagolysosomal vacuole. Indeed, they have on their surface at least one powerful hydrolase of their own, an acid phosphatase. This enzyme has been found to inhibit superoxide anion production by human neutrophils activated with the chemoattractant peptide f-Met-Leu-Phe. The phosphatase apparently acts on the receptor for the formylated peptide activator. One leishmania contains enough acid phosphatase to reduce by 50% the superoxide anion production of three neutrophils. Since the enzyme has the same effect on macrophages, this may help to explain the reduced respiratory bursts elicited by amastigotes of Leishmania. No doubt other enzymes will be found that help Leishmania to live and grow in the adverse conditions of a phagolysosome.
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Bibliography
Barrai, A., Petersen, E. A., Sacks, D. L., and Neva, F. A., 1983, Late metastatic leishmaniasis in the mouse: A model for mucocutaneous disease, Am. J. Trop. Med. Hyg. 32:277–285.
Blackwell, J. M., 1982, Genetic control of recovery from visceral leishmaniasis, Trans. R. Soe. Trop. Med. Hyg. 76:147–151.
Blackwell, J., Freeman, J., and Bradley, D., 1980, Influence of H-2 complex on acquired resistance to Leishmania donovani infection in mice, Nature 283:72–74.
Brener, Z., 1980, Immunity to Trypanosoma cruzi, Adv., Parasitol 18:247–292.
Chang, K.-P., 1983, Cellular and molecular mechanisms of intracellular symbiosis in leishmaniasis, Int. Rev. Cytol (Suppl.) 14:267–305.
Channon, J. Y., Roberts, M. B., and Blackwell, J. M., 1984, A study of the differential respiratory burst activity elicited by promastigotes and amastigotes of Leishmania donovani in murine resident peritoneal macrophages, Immunology 53:345–354.
De Souza, W., 1984, Cell biology of Trypanosoma cruzi, Int. Rev. Cytol. 86:197–283.
Garnham, P. C. C., and Humphrey, J. H., 1969, Problems in leishmaniasis related to immunology, Curr. Top. Microbiol Immunol. 48:29–42.
Grimaud, J. A., and Andrade, S. A., 1984, Trypanosoma cruzi: Intracellular host-parasite relationship in murine infection, Cell. Mol. Biol. 30:59–65.
Handman, E., and Mitchell, G. F., 1985, Immunization with Leishmania receptor for macrophages protects mice against cutaneous leishmaniasis, Proc. Natl. Acad. Sci. USA 82:5910–5914.
Howard, J. G., and Liew, F. Y., 1984, Mechanisms of acquired immunity in leishmaniasis, Philos. Trans. R. Soc. London Ser. B 307:87–98.
Hudson, L., 1983, Trypanosoma cruzi: The immunological consequences of infection, J. Cell. Biochem. 21:299–304.
Hudson, L., 1983, Immunopathogenesis of experimental Chagas’ disease in mice: Damage to the autonomic nervous system, Ciba Found. Symp. 99:234–246.
Jones, T. C., 1981, Interactions between murine macrophages and obligate intracellular protozoa, Am. J. Pathol. 102:127–132.
Kierszenbaum, F., and Sonnenfeld, G., 1984, β-Interferon inhibits cell infection by Trypanosoma cruzi, J. Immunol. 132:905–908.
Köberle, F., 1974, Pathogenesis of Chagas’ disease, Ciba Found. Symp. 20:137–158.
Krassner, S. M., Granger, B., Morrow, C., and Granger, G., 1982, In vitro release of lymphotoxin by spleen cells from C3H/HeJ and C57BL/6 mice infected with Trypanosoma cruzi, Am. J. Trop. Med. Hyg. 31:1080–1089.
Louis, J. A., Zubler, R. H., Coutinko, S. G., Lima, G., Behin, R., Mouel, J., and Engers, H. D., 1982, The in vitro generation and functional analysis of murine T cell populations and clones specific for a protozoan parasite Leishmania tropica, Immunol. Rev. 61:215–243.
Mauel, J., 1982, In vitro induction of intracellular killing of parasitic protozoa by macrophages, Immunobiology 161:392–400.
Mauel, J., 1984, Mechanisms of survival of protozoan parasites in mononuclear phagocytes, Parasitology 88:579–592.
Nguyen, T. V., Mauel, J., Etges, R. J., Bouvier, J., and Bordier, C., 1984, Immunogenic proteins of Leishmania major during mouse infection, Parasite Immunol. 6:265–273.
Nogueira, N., and Coura, J. R., 1984, American trypanosomiasis (Chagas’ disease), in: Tropical and Geographical Medicine (K. S. Warren and A. A. F. Mahmoud, eds.), McGraw-Hill, New York, pp. 253–269.
Oster, C. N., and Nagy, C. A., 1984, Macrophage activation to kill Leishmania tropica: Kinetics of macrophage response to lymphokines that induce antimicrobial activities against amastigotes, J. Immunol. 132:1494–1500.
Plata, F., Wietzerbin, J., Pons, F. G., Falcoff, E., and Elsen, H., 1984, Synergistic protection by specific antibodies and interferon against infection by Trypanosoma cruzi, Eur. J. Immunol. 14:930–935.
Poulter, L. W., 1979, The kinetics and quality of acquired resistance in self-healing and metastatic leishmaniasis, Clin. Exp. Immunol. 36:30.
Poulter, L. W., 1980, Mechanisms of immunity to leishmaniasis. II. Significance of the intramacrophage localization of the parasite, Clin. Exp. Immunol. 40:25–35.
Ramaley, A. T., Kuhns, D. B., Basford, R. E., Glew, R. H., and Kaplan, S. S., 1984, Leishmanial phosphatase blocks neutrophil O−2 production, J. Biol. Chem. 259:11173–11175.
Ribeiro dos Santos, R., and Hudson, L., 1980, Trypanosoma cruzi: Immunological consequences of parasite modification of host cells, Clin. Exp. Immunol. 40:36–41.
Rowin, K. S., Tanowitz, H. B., Wittner, M., Nguyen, H. T., and Nadel-Ginard, B., 1983, Inhibition of muscle differentiation by Trypanosoma cruzi, Proc. Natl. Acad. Sci. USA 80:6390–6394.
Sacks, D. L., Scott, P. A., Asofsky, R., and Sher, F. A., 1984, Cutaneous leishmaniasis in anti-IgM-treated mice: Enhanced resistance due to functional depletion of a B cell-dependent T cell involved in the suppressor pathway, J. Immunol. 132:2072–2077.
Scott, M. T., and Snary, D., 1979, Protective immunization of mice using cell surface glycoprotein from Trypanosoma cruzi, Nature 282:73–74.
Slutzky, G. M., El-On, J., and Greenblatt, C. L., 1979, Leishmanial excreted factor: Protein-bound and free forms from promastigote cultures of Leishmania tropica and Leishmania donovani, Infect. Immun. 26:916–924.
Teixeira, A. R. L., 1979, Chagas’ disease: Trends in immunological research and prospects for immunoprophylaxis, Bull. WHO 57:697–710.
Turco, S. J., Wilkerson, M. A., and Clawson, D. R., 1984, Expression of an unusual acidic glycoconjugate in Leishmania donovani, J. Biol. Chem. 259:3883–3889.
Villalta, F., and Kierszenbaum, F., 1983, Immunization against a challenge with insect vector, metacyclic forms of Trypanosoma cruzi simulating a natural infection, Am. J. Trop. Med. Hyg. 32:273–276.
Wood, J. N., Hudson, L., Jessell, T. M., and Yamamoto, M., 1982, A monoclonal antibody defining antigenic determinants on subpopulations of mammalian neurons and Trypanosoma cruzi parasites, Nature 296:34–38.
Wrightsman, R., Krassner, S., and Watson, J., 1982, Genetic control of responses to Trypanosoma cruzi in mice: Multiple genes influencing parasitemia and survival, Infect. Immun. 36:637–644.
Zehavi, U., Abrahams, J. C., Granoth, R., Greenblatt, C. L., Slutzky, G. M., and El-On, J., 1983, Leishmanial excreted factors (EFs): Purification by affinity chromatography, Z. Parasitenkd. 69:695–701.
Zuckerman, A., and Lainson, R., 1977, Leishmania, in: Parasitic Protozoa, Volume I (J. P. Kreier, ed.), Academic Press, New York, pp. 57–133.
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© 1986 Plenum Press, New York
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Trager, W. (1986). Immunology of Leishmaniasis and American Trypanosomiasis (Chagas’ Disease). In: Living Together. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9465-9_20
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DOI: https://doi.org/10.1007/978-1-4615-9465-9_20
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