Abstract
For any individual in the population the determination of lipid levels is multifactorial. By studying the population as a whole it is possible to get a better definition of these factors. In the case of cholesterol, for example, we know from a number of studies that 50% of the total phenotypic variance in the population is due to environmental factors and 50% due to genetic factors, with variation at a number of genetic loci contributing to this genetic component of cholesterol variance 1 , 2. Apo B plays a central role in lipid metabolism as ligand for the LDL receptor and epidemiological studies have shown that increased apo B levels correlate with increased risk of coronary heart disease 3. Thus variation in the apo B gene could be involved in determining cholesterol levels and hence atherosclerosis risk.
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© 1989 Plenum Press, New York
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Talmud, P., Houlston, R., Dunning, A., Humphries, S. (1989). Apo B Gene Variants are Involved in Determining Serum Cholesterol Levels: Towards Identifying these Variants. In: Sirtori, C.R., Franceschini, G., Brewer, H.B., Assmann, G. (eds) Human Apolipoprotein Mutants 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9549-6_10
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DOI: https://doi.org/10.1007/978-1-4615-9549-6_10
Publisher Name: Springer, Boston, MA
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