Abstract
Gestational diabetes mellitus (GDM) affects placental composition and intrinsic metabolism both in humans (1) and rats (2), and causes abnormalities in maternal-fetal metabolite tranfer (3). These changes may actively contribute to the altered fetal growth that occurs in GDM, which directly depends on the quality and quantity of metabolic fuels crossing the placenta. These fuels may be used as building blocks for fetal accretion and also modulate fetal beta-cell insulin release which is recognized as an important growth factor for the fetus (4).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Y.Z. Diamant, B.E. Metzger, N. Freinkel and E. Shafrir, Placental lipid and glycogen content in human and experimental diabetes mellitus, Am. J. Obstet.Gynecol. 144: 5 (1982).
V. Barash, A. Gutman and E. Shafrir, Fetal diabetes in rats and its effect on placental glycogen, Diabetologia 28: 244 (1985).
E. Herrera, M. Palacín, A. Martín and M.A. Lasunción, Relationship between maternal and fetal fuels and placental glucose transfer in rats with maternal diabetes of varying severity, Diabetes 34 (suppl.2): 42 (1985).
P.S. Cooke and C.S. Nicoll, Role of insulin in the growth of fetal rat tissues, Endocrinology 114: 638 (1984).
M. A. Lasunción, X. Testar, M. Palacín, R. Chieri and E. Herrera, Method for the study of metabolite transfer from rat mother to the fetus, Biol. Neonate 44: 83 (1983).
M. Palacín, M.A. Lasunción, A. Martín and E. Herrera, Decreased uterine blood flow in the diabetic pregnant rat does not modify the augmented glucose tranfer to the fetus, Biol.Neonate 48: 197 (1985).
J.M. Cuezva, E.S. Burkett, D.S. Kerr, H.M. Rodman and M. S. Patel, The newborn of diabetic rat. I. Hormonal and metabolic changes in the postnatal period, Pediat.Res. 16: 632 (1982).
L. L.H. Peeters, J. W. Sparks, G. Grutters, J. Girard and F.C. Battaglia, Utero-placental blood flow during pregnancy in chronically catheterized guinea pigs, Pediat.Res. 16: 716 (1982).
P. Rosso and R. Kava, Effects of food restriction on cardiac output and blood flow to the uterus and placenta in the pregnant rat, J.Nutr. 110: 2350 (1980).
R. A. Rhoades and D.A. Ryder, Fetal lung metabolism, response to maternal fasting, Biochim. Biophys. Acta 663: 621 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Martín, A., Palacín, M., Lasunción, M.A., Herrera, E. (1990). Fetal/Maternal Plasma Amino Acid Relationships in the Streptozotocin Diabetic Rat. In: Cuezva, J.M., Pascual-Leone, A.M., Patel, M.S. (eds) Endocrine and Biochemical Development of the Fetus and Neonate. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9567-0_29
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9567-0_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9569-4
Online ISBN: 978-1-4615-9567-0
eBook Packages: Springer Book Archive