Abstract
Of the [3H]choline newly taken up into small slices of frontal cortex, a larger fraction is acetylated in samples from adult rats than in samples from 7–14 day olds (Atterwill & Prince, 1978). This developmental change is apparent whether acetylation is expressed as a fraction of total uptake, or of uptake corrected for that in sodium-free medium (Kalaria et al., 1980). The increasing acetylation with age may reflect increasing concentrations of choline acetyltransferase (ChAT, EC 2.3.1.6) in the cortex during development. More specifically, it may reflect increasing concentrations of the basic molecular form of rat brain ChAT (Atterwill & Prince, 1978), which has appreciable affinity for synaptosomal membrane fragments (Fonnum & Malthe-Sørenssen, 1973).
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© 1981 C.J. Pycock and P.V. Taberner
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Atterwill, C.K., Prince, A.K., Reynolds, R., Wong, P.TH. (1981). Species Differences in the Acetylation of [3H] Choline in Cortical Slices. In: Pycock, C.J., Taberner, P.V. (eds) Central Neurotransmitter Turnover. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9778-0_11
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DOI: https://doi.org/10.1007/978-1-4615-9778-0_11
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