Abstract
The effect of acute and chronic ingestion of aspartame was studied in normal and streptozotocin-induced diabetic rats. In both groups, a single dose of aspartame caused an increase of approximately 12% in liver tryptophan oxygenase (TO) activity. In diabetic animals, the sweetener caused a decrease in blood and brain tryptophan and an increase in serum glucose and glucagon. Chronic ingestion of aspartame also caused increase in TO activity in both groups. It caused a decrease in fasting serum insulin in normal animals and an increase in serum glucose in diabetic animals. Aspartame may adversely affect the capacity to control glucose metabolism in the diabetic.
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© 1988 Birkhäuser Boston
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Sardesai, V.M., Holliday, J.F., Kumar, G.K., Dunbar, J.C. (1988). Effect of Aspartame in Diabetic Rats. In: Wurtman, R.J., Ritter-Walker, E. (eds) Dietary Phenylalanine and Brain Function. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9821-3_33
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DOI: https://doi.org/10.1007/978-1-4615-9821-3_33
Publisher Name: Birkhäuser Boston
Print ISBN: 978-1-4615-9823-7
Online ISBN: 978-1-4615-9821-3
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