Abstract
In the search for bioactive compounds from marine sources, the selection of specific organisms and classes of compounds to be studied is dictated by bioassay, rather than the conscious choice of the investigator. As a result, efforts are often not focused on a given phylum or class of compounds. Instead, animals from different phyla and compounds varying greatly in size, type, and structural complexity are dealt with. The collection of different organisms and assorted types of natural products described in this paper illustrates these points.
Dr. Schmitz has requested that the authorship of this paper be quoted as follows: F. J. Schmitz, D. C. Campbell, K. Hollenbeak, D. J. Vanderah, L. S. Ciereszko, P. Steudler, J. D. Ekstrand, D. van der Helm, P. Kaul, and S. Kulkarni.
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References
F. J. McDonald, D. C. Campbell, D. J. Vanderah, F. J. Schmitz, D. M. Washecheck, J. E. Burks, and D. van der Helm, J. Org. Chem. 40, 665 (1975).
R. I. Gueran, N. H. Greenberg, M. M. MacDonald, A. M. Schumacher and B. J. Abbott, Cancer Chemother. Rep. Part 3, 3, No. 2 (Sept. 1972). P388 = cell culture of lymphocytic leukemia; in vitro activity (ED50) is measured as the dose in μg/ml that causes 50% inhibition of growth; ED50’s of less than 10 are considered active. PS = lymphocytic leukemia assay in mice; T/C % = (survival time of treated animals)/(control’s survival time) X 100; values >125 are considered active. KB = cell culture of human epidermoid carcinoma of the nasopharynx; activity is measured as for P388.
M. H. Baslow, Marine Pharmacology, The Williams and Wilkins Co., Baltimore, 1969, p. 86.
H. L. Bradlow and C. A. Vanderwerf, J. Org. Chem. 16, 1143 (1951).
F. J. Schmitz and F. J. McDonald, Tetrahedron Lett., 2541 (1974); (b) Unpublished results.
D. J. Vanderah and F. J. Schmitz, J. Org. Chem., in press.
100 MHz (CDCI3) 1.07(d, 3, 2°-Me), 1.24 (s, 3, 3°-Me), 1.68 (br s, 3, vinyl Me), 4.73 (m, 2, = CH2), 5.36 (br m, 1,-CH=C(CH3)-), 5.94 (ABq, 1, J = 12, 16,-CH=CH), 5.06 (dd, 1, J = 12, 2,-CH=CH2), 5.20 (dd, 1, J = 16, 2,-CH=CH2).
T. K. Devon and A. I. Scott, Handbook of Naturally Occurring Compounds, Vol. II, Academic Press, New York and London, p. 153.
F. J. Schmitz, D. J. Vanderah, and L. S. Ciereszko, Chem. Coram., 407 (1974).
Calcd for C28H38O9: C, 64.86; H, 7.38; M+ 518.2518; Found: C, 64.90; H, 7.32, M+ 518.24888.
D. J. Vanderah, P. A. Steudler, L. S. Ciereszko, F. J. Schmitz, J. D. Ekstrand, and D. van der Helm, J. Am. Chem. Soc., submitted.
J. B. Hendrickson, Tetrahedron 7, 82 (1959).
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© 1977 Plenum Press, New York
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Schmitz, F.J. (1977). Chemistry Related to the Search for Drugs from the Sea. In: Faulkner, D.J., Fenical, W.H. (eds) Marine Natural Products Chemistry. Nato Conference Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0802-7_24
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DOI: https://doi.org/10.1007/978-1-4684-0802-7_24
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