Skip to main content

Physiology of the Placenta

  • Chapter
Principles and Prenatal Growth

Abstract

Retention of the fetus within the mother offers many obvious survival advantages. A wealth of experimentation towards achieving this objective is already found among fishes, and early forms of the placenta can be identified (Amoroso, 1952). Placentation achieves its most complex development in the mammal. Two of the fetal membranes which are easily recognizable in egg-laying animals, the chorion and allantois, are extensively modified to provide the fetal contribution to the placenta. The maternal component of the placenta varies in the different species. The uterus, which is developed for retention of the embryo, also contributes the maternal vasculature. Within the placenta, maternal and fetal vessels lie in intimate juxtaposition, facilitating the exchange of nutrients and waste products.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adcock, E. W., III, Teasdale, F., August, C. S., Cox, S., Meschia, G., Battaglia, F. C., and Naughton, M. A., 1973, Human chorionic gonadotropin: Its possible role in maternal lymphocyte suppression, Science 181:845.

    Article  Google Scholar 

  • Amoroso, E. C, 1952, Placentation, in: Marshall’s Pysiology of Reproduction (A. S. Parkes, ed.), pp. 127–311, Spottiswoode, Ballantyne, London.

    Google Scholar 

  • Andrews, P., 1969, Molecular weight of human placental lactogen investigated by gel filtration, Biochem. J. 111:799.

    Google Scholar 

  • Awai, M., Chipman, B., and Brownes, E. B., 1975 In vivo evidence for the functional heterogeneity of transferrin bound iron. I. Studies in normal rats, J. Lab. Clin. Med. 85:769.

    Google Scholar 

  • Awai, M., Chipman, B., and Brownes, E. B., 1975/?, In vivo evidence for the functional heterogeneity of transferrin bound iron. II. Studies in pregnant rats, J. Lab. Clin. Med. 85;785.

    Google Scholar 

  • Baerlocher, K. E., Scriver, C. R., and Mohyuddin, F., 1970, Ontogeny of iminoglycine transport in mammalian kidney, Proc. Natl. Acad. Sci. U.S.A. 65:1009.

    Article  Google Scholar 

  • Barnes, A. C, 1951, The placental metabolism of vitamin A, Am. J. Obstet. Gynecol. 61:368.

    Google Scholar 

  • Bartels, H., 1970, Prenatal respiration, in: Frontiers of Biology, Vol. 17 (A. Neuberger and E. L. Tatum, eds.), pp. 1–187, North-Holland, Amsterdam.

    Google Scholar 

  • Bartels, H., Moll, W., and Metcalfe, J., 1962, Physiology of gas exchange in the human placenta, Am. J. Obstet. Gynecol. 84:1714.

    Google Scholar 

  • Bashore, R. A., Smith, F., and Schenker, S., 1969, Placental transfer and disposition of bilirubin in the pregnant monkey, Am. J. Obstet. Gynecol. 103:950.

    Google Scholar 

  • Battaglia, F. C, Behrman, R. E., Meschia, G., Seeds, A. E., and Bruns, P. D., 1968, Clearance of inert molecules, Na and Cl ions across the primate placenta, Am. J. Obstet. Gynecol. 102:1135.

    Google Scholar 

  • Bauer, C, Ludwig, I., and Ludwig, M., 1968, Different effects of 2,3-diphosphoglycerate and adenosine triphosphate on the oxygen affinity of adult and foetal human haemoglobin, Life Sci. 17:1339.

    Article  Google Scholar 

  • Beer, A. E., and Billingham, R. E., 1973, Maternally acquired runt disease, Science 179:240.

    Article  Google Scholar 

  • Beer, A. E., and Billingham, R. E., 1974, Immunologie coexistence in the maternal-fetal relationship, in: Modern Perinatal Medicine (L. Gluck, ed), p. 83, Year-Book Medical Publishers, Chicago.

    Google Scholar 

  • Beer, A. E., Billingham, R. E., and Scott, J. R., 1975, Immunogenetic aspects of implantation, placentation and feto-placental growth rates, Biol. Reprod. 12:176.

    Article  Google Scholar 

  • Beischer, N. A., and Brown, J. B., 1972, Current status of estrogen assays in obstetrics and gynecology, Obstet. Gynecol. Surv. 27:303.

    Google Scholar 

  • Beitins, I. Z., Bayard, F., Ances, I. G., Kowarski, A., and Migeon, C. J., 1973, The metabolic clearance rate, blood production, interconversion and transplacental passage of cortisol and cortisone in preenancv near term. Pediatr. Res. 7:509.

    Article  Google Scholar 

  • Bellisario, R., Carlson, R. B., and Bahl, O. P., 1973, Human chorionic gonadotropin. Linear amino acid sequence of the α subunit, J. Biol. Chem. 248:6796.

    Google Scholar 

  • Biezenski, J. J., 1969, Role of placenta in fetal lipid metabolism. I. Injection of phospholipids double labeled with C14 glycerol and P32 into pregnant rabbits, Am. J. Obstet. Gynecol. 104:1177.

    Google Scholar 

  • Boger, W. P., Bayne, G. M., Wright, L. D., and Beck, G. D., 1957, Differential serum vitamin B12 concentrations in mothers and infants, N Engl. J. Med. 256:1085.

    Article  Google Scholar 

  • Bothwell, T. H., Pribella, W. F., Mebust, W., and Finch, C. A., 1958, Iron metabolism in the pregnant rabbit: Iron transport across the placenta, Am. J. Physiol. 193:615.

    Google Scholar 

  • Boyd, R. D. H., Morris, F. H., Meschia, G., Makowski, E. L., and Battaglia, F. C., 1973, Growth of glucose and oxygen uptake by fetuses of fed and starved ewes, Am. J. Physiol. 225:897.

    Google Scholar 

  • Brambell, F. W. R., Hemming, W. A., and Henderson, M., 1951, Antibodies and Embryos, Athlone Press, London.

    Google Scholar 

  • Braunstein, G. D., Grodin, J. M., Vaitukaitis, J. L., and Ross, G. T., 1973, Secretory rates of human chorionic gonadotropin by normal trophoblast, Am. J. Obstet. Gynecol. 115:447.

    Google Scholar 

  • Brans, P. D., Linder, R. O., Drose, V. E., and Battaglia, F., 1963, The placental transfer of water from fetus to mother following the intravenous infusion of hypertonic mannitol to the maternal rabbit, Am. J. Obstet. Gynecol. 86:160.

    Google Scholar 

  • Brans, P. D., Hellegers, A. E., Seeds, A. E., Jr., Behrman, R. E., and Battaglia, F. C, 1964, Effects of osmotic gradients across the primate placenta upon fetal and placental water contents, Pediatrics 34:407.

    Google Scholar 

  • Burd, L. J., Jones, M. D., Jr., Simmons, M. A., Makowski, E. L., Meschia, G., and Battaglia, F. C., 1975, Placental production and fetal utilization of lactate, Nature 254:710.

    Article  Google Scholar 

  • Campbell, A. G. M., Dawes, G. S., Fishman, A. P., Human, A. J., and James, G. B., 1966, The oxygen consumption of the placenta and fetal membranes in the sheep, J. Physiol. (London) 182:439.

    Google Scholar 

  • Carlsen, R. B., Bahl, O. P., and Swaminathan, N., 1973, Human chorionic gonadotropin. Linear aminoacid sequence of the β subunit, J. Biol. Chem. 248:6810.

    Google Scholar 

  • Cedard, L., Tehobronsky, C, Guglielmina, R., and Mailhac, M., 1971, Insuffisance oestrogénique paradoxale au cours d’une grossesse normal par défaut de sulfataseplacentaire, Bull. Fed. Soc. Gynecol. Obstet. Lang. Fr. 23:16.

    Google Scholar 

  • Challier, J. C, Schneider, H., and Dancis, J., 1976, In vitro perfusion of human placenta. V. Oxygen consumption, Am. J. Obstet. Gynecol. 126:261–265.

    Google Scholar 

  • Chan, H. L., Dixon, J. S., and Chung, D., 1971, Primary structure of the human chorionic somatomam-motropin (HCS) molecule, Science 173:56.

    Article  Google Scholar 

  • Contractor, S. F., and Davies, H., 1973, Effect of human chorionic somatomammotropin and human chorionic gonadotropin on phytohaemagglutinin-induced lymphocyte transformation, Nature (London), New Biol. 243:284.

    Article  Google Scholar 

  • Contractor, S. F., and Shane, B., 1970, Blood and urine levels of vitamin B6 in the mother and fetus before and after loading of the mother with vitamin B6, Am. J. Obstet. Gynecol. 107:635.

    Google Scholar 

  • Csapo, A. J., 1973, The effect of E2 replacement therapy on early pregnant lutectomized patients, Am. J. Obstet. Gynecol. 117:987.

    Google Scholar 

  • Currie, G. A., Van Dominick, W., and Bagshawe, K. D., 1968, Effects of neuraminidase on the immunogenecity of early mouse trophoblast, Nature 219:191.

    Article  Google Scholar 

  • Dancis, J., 1959, Aspects of bilirubin metabolism before and after birth, Pediatrics 24:980.

    Google Scholar 

  • Dancis, J., and Springer, D., 1970, Fetal homeostasis in maternal malnutrition: Potassium and sodium deficiency, Pediatr. Res. 4:345.

    Article  Google Scholar 

  • Dancis, J., Braverman, N., and Lind, J., 1957a, Plasma protein synthesis in the human fetus and placenta, J. Clin. Invest. 36:398.

    Article  Google Scholar 

  • Dancis, J., Worth, M., Jr., and Schneidau, P. B., 1957b, Effect of electrolyte disturbance in the pregnant rabbit on the fetus, Am. J. Physiol. 188:535.

    Google Scholar 

  • Dancis, J., Lind, J., Oratz, M., Smolens, J., and Vara, P., 1961, Placental transfer of proteins in human gestation, Am. J. Obstet. Gynecol. 82:167.

    Google Scholar 

  • Dancis, J., Brenner, M., and Money, W. L., 1962, Some factors affecting the permeability of guinea pig placenta, Am. J. Obstet. Gynecol. 84:570.

    Google Scholar 

  • Dancis, J., Jansen, V., Gorstein, F., and Douglas, G., 1968a, Hematopoietic cells in mouse placenta, Am. J. Obstet. Gynecol. 100:1110.

    Google Scholar 

  • Dancis, J., Money, W. L., Springer, D., and Levitz, M., 1968/?, Transport of amino acids by placenta, Am. J. Obstet. Gynecol. 101:820.

    Google Scholar 

  • Dancis, J., Springer, D., and Cohlan, S. Q., 1971, Fetal homeostasis in maternal malnutrition. II. Magnesium deprivation, Pediatr. Res. 5:131.

    Article  Google Scholar 

  • Dancis, J., Jansen, V., Kayden, H. J., Schneider, H., and Levitz, M., 1973, Transfer across perfused human placenta. II. Free fatty acids Pediatr. Res. 7:192.

    Article  Google Scholar 

  • Dancis, J., Jansen, V., and Levitz, M., 1976, Transfer across perfused human placenta. IV. Effect of protein binding on free fatty acids, Pediatr. Res. 10:5.

    Article  Google Scholar 

  • Davies, J., 1955, Permeability of the rabbit placenta to glucose and fructose, Am. J. Physiol. 181:532.

    Google Scholar 

  • Dawes, G. S., and Shelley, H. J., 1968, Carbohydrate metabolism in the fetus and newborn, in: Carbohydrate Metabolism (F. Dickens, ed.), pp. 87–121, Academic Press, New York.

    Google Scholar 

  • Delivoria-Papadopoulos, M., Battaglia, F. C, Bruns, P. D., and Meschia, G., 1967, Total protein-bound and ultrafiltrable calcium in maternal and fetal plasmas, Am. J. Physiol. 213:363.

    Google Scholar 

  • Demers, L. M., Gabbe, S. G., Villee, C. A., and Greep, R. D., 1972, The effects of insulin on human placental glycogenesis, Endocrinology 91:270.

    Article  Google Scholar 

  • Delkonikoff, L. K., and Cedard, L., 1973, Localization of human chorionic gonadotropic and somato-mammotropic hormones by the peroxidase immunohistoenzymologic method in villi and amniotic epithelium of human placentas (from six weeks to term), Am. J. Obstet. Gynecol. 116:1124.

    Google Scholar 

  • Diczfalusy, E., Tillinger, K. F., Wiqvist, N., Levitz, M., Condon, G. P., and Dancis, J., 1963, Disposition of intra-amniotically administered estriol-16-14C and estrone-16-14C sulfate by women, J. Clin. Endocrinol. Metab. 23:503.

    Article  Google Scholar 

  • Dierks-Vending, C, Cone, A. L., and Wapnir, R. A., 1971, Placental transfer of amino acids in the rat. I. L-Glutamic acid and L-glutamine, Biol. Neonat. 17:361.

    Article  Google Scholar 

  • DiPietro, D. L., Gutierrez-Correa, J., and Thaidigman, J. H., 1967, Glucose metabolism by human placental villi, Biochem. J. 103:246.

    Google Scholar 

  • Dreskin, R. B., Spicer, S. S., and Greene, W. B., 1970, Ultrastructural localization of chorionic gonadotropin in human term placenta, J. Histochem. Cytochem. 18:862.

    Article  Google Scholar 

  • Earle, D. P., Bakwin, H., and Hirsch, D., 1951, Plasma potassium level in newborn, Proc. Soc. Exp. Biol. Med. 76:756.

    Google Scholar 

  • Elson, J., Jenkinson, E. J., and Billington, W. D., 1975, Fc receptors on mouse placenta and yolk sac cells, Nature 255:412.

    Article  Google Scholar 

  • Faber, J. J., and Hart, F. M., 1966, The rabbit placenta as an organ of diffusional exchange. Comparison with other species by dimensional analysis, Circ. Res. 19:816.

    Article  Google Scholar 

  • Fantel, A. G., 1975, Feto-maternal potassium relations in the fetal rat on the twentieth day of gestation, Pediatr. Res. 9:527.

    Article  Google Scholar 

  • Faulk, W. P., 1974, Immunological studies of the human placenta. Characterization of immunolgobulins on trophoblastic basement membranes, J. Clin. Invest. 54:1011.

    Article  Google Scholar 

  • Flexner, L. B., and Gellhorn, A., 1942, The comparative physiology of placental transfer, Am. J. Obstet. Gynecol. 43:965.

    Google Scholar 

  • Flexner, L. B., Cowie, D. B., Hellman, L. M., Wilde, W. S., and Vosburgh, G. J., 1948, The permeability of the human placenta to sodium in normal and abnormal pregnancies and the supply of sodium to the human fetus as determined with radioactive sodium, Am. J. Obstet. Gynecol. 55:469.

    Google Scholar 

  • Folkart, G. R., Dancis, J., and Money, W. L., 1960, Transfer of carbohydrates across guinea pig placenta, Am. J. Obstet. Gynecol. 80:221.

    Google Scholar 

  • Friedman, E. A., and Sachtleben, M. R., 1960, Placental oxygen consumption in vitro. I. Baseline studies, Am. J. Obstet. Gynecol. 79:1058.

    Google Scholar 

  • Gant, N. F., Hutchinson, H.’ T., Siiteri, P. K., and MacDonald, P. C, 1971, Study of the metabolic clearance rate of dehydroepiandrosterone sulfate in pregnancy, Am. J. Obstet. Gynecol. 111:555.

    Google Scholar 

  • Gaull, G. E., Raiha, N. C. R., Saarikoski, S., and Sturman, J. A., 1973, Transfer of cyst(e)ine and methionine across the human placenta, Pediatr. Res. 7:908.

    Article  Google Scholar 

  • Genazzani, A. R., 1974, In vitro synthesis of an ACTH like hormone and HCS by placental and amniotic cells, Experientia 30:430.

    Article  Google Scholar 

  • Genazzani, A. R., 1975, Immunoreactive ACTH and cortisol plasma levels during pregnancy, Clin. Endocrinol. 4:1.

    Article  Google Scholar 

  • Ghadimi, H., and Pecora, P., 1964, Free amino acids of cord plasma as compared with maternal plasma during pregnancy, Pediatrics 33:500.

    Google Scholar 

  • Gibbons, J. M., Mitnick, M., and Chieffo, V., 1975, In vitro biosynthesis of TSH-and LH-releasing factors by the human placenta, Am. J. Obstet. Gynecol. 121:127.

    Google Scholar 

  • Gitlin, J. D., 1974, Protein-binding by specific receptors on human placenta, murine placenta and suckling murine intestine in relation to protein transport across these tissues, J. Clin. Invest. 54:1155.

    Article  Google Scholar 

  • Gitlin, D., Kumate, J., and Morales, C., 1965, On the transport of insulin across the human placenta, Pediatrics 35:65.

    Google Scholar 

  • Glendening, M. B., Margolis, A. J., and Page, E. W., 1961, Amino acid concentrations in fetal and maternal plasma, Am. J. Obstet. Gynecol. 81:591.

    Google Scholar 

  • Goldwater, W. H., and Stetten, De W., Jr., 1947, Studies in fetal metabolism, J. Biol. Chem. 169:722.

    Google Scholar 

  • Gresham, E. L., James, E. J., Raye, J. R., Battaglia, F. C, Makowski, E. L., and Meschia, G., 1971, Production and excretion of urea by the fetal lamb, Pediatrics 50:372.

    Google Scholar 

  • Grossowicz, N., Aronovitch, J., Rachmilewitz, M., Izak, G., Sadovsky, A., and Bercovici, B., 1960, Folk and folinic acid in maternal and foetal blood, Br. J. Haematol. 6:296.

    Article  Google Scholar 

  • Gruenwald, P., 1975, Introduction, the supply Une of the fetus: Definitions relating to fetal growth, in: The Placenta and Its Maternal Supply Line (P. Gruenwald, ed.), pp. 1–17, Medical and Technical Publishing, Lancaster, Great Britain.

    Google Scholar 

  • Gurtner, G., and Burns, B., 1975, Physiological evidence consistent with the presence of specific O2 carrier in the placenta, J. Appl. Physiol. 39:728.

    Google Scholar 

  • Hagerman, D. D., and Villee, C. A., 1952, Transport of fructose by human placenta, J. Clin. Invest. 31:911.

    Article  Google Scholar 

  • Haour, F., and Bertrand, J., 1974, Insulin receptors in the plasma membranes of human placenta, J. Clin. Endocrinol. Metab. 38:334.

    Article  Google Scholar 

  • Haskins, A. L., and Soiva, K. U., 1960, The placental transfer of progesterone-4-14C in human term pregnancy, Am. J. Obstet. Gynecol. 79:674.

    Google Scholar 

  • Hellegers, A., Okuda, K., Nesbitt, R. E. L., Jr., Smith, D. W., and Chow, B. F., 1957, Vitamin B12 absorption in pregnancy and in the newborn, Am. J. Clin. Nutr. 5:327.

    Google Scholar 

  • Heilig, H., Gattereau, D., Lefebvre, C, and Boite, E., 1970, Steroid production from plasma cholesterol to placental progesterone in humans, J. Clin. Endocrinol. 30:624.

    Article  Google Scholar 

  • Hellstrom, K. A., Hellstrom, J., and Brawn, J., 1969, Abrogation of cellular immunity to antigenetically foreign mouse embryonic cells by a serum factor, Nature 224:914.

    Article  Google Scholar 

  • Hennen, G., Pierce, J. G., and Treychet, P., 1969, Human chorionic thyrotropin: Further characterization and study of its secretion during pregnancy, J. Clin. Endocrinol. Metab. 29:581.

    Article  Google Scholar 

  • Hensleigh, P. A., and Krantz, K. E., 1966, Extracorporeal perfusion of the human placenta. I: Placental transfer of ascorbic acid, Am. J. Obstet. Gynecol. 96:5.

    Google Scholar 

  • Hershfield, M. S., and Nemeth, A. M., 1968, Placental transport of free palmitic and lineolic acids in the guinea pig, J. Lipid Res. 9:460.

    Google Scholar 

  • Hershman, J. M., and Starnes, W. R., 1971, Placental content and characterization of human chorionic thyrotropin, J. Clin. Endocrinol. Metab. 32:52.

    Article  Google Scholar 

  • Hill, P. M. M., and Young, M., 1973, Net placental transfer of free amino acids against varying concentrations, J. Physiol. 235:409.

    Google Scholar 

  • Hillman, L. S., and Haddad, J., 1974, Human prenatal vitamin D metabolism I: 25 hydroxyvitamin D in maternal and cord blood, J. Pediatr. 84:742.

    Article  Google Scholar 

  • Hirsch, J., Farquhar, J., Ahrens, E. H., Jr., Peterson, M. L., and Stoffel, W., 1960, Studies of adipose tissue in man. A microtechnic for sampling and analysis, Am. J. Clin. Nutr. 8:499.

    Google Scholar 

  • Holmberg, N. G., Kaplan, B., Karvonen, M. J., Lind, J., and Malm, M., 1956, Permeability of human placenta to glucose, fructose and xylose, Acta Physiol. Scand. 36:291.

    Article  Google Scholar 

  • Josimovich, J. B., and MacLaren, J. A., 1962, Presence in the human placenta and term serum of a highly lactogenic substance immunologically related to pituitary growth hormone, Endocrinology 71:209.

    Article  Google Scholar 

  • Josimovich, J. B., Levitt, M. J., Grumbach, M. M., Kaplan, S. L. and Vinik, A., 1973, Human chorionic somatomammotropin (HCS), in: Methods in Investigative and Diagnostic Endocrinology (S. A. Berson, ed), pp. 787–822, North Holland, Amsterdam.

    Google Scholar 

  • Kadowaki, J., Thompson, R. J., Zuelzer, W. W., Wooley, P. V., Jr., Brough, A. J., and Gruber, D., 1965, XX-XY lymphoid chimaerism in congenital immunological deficiency syndrome with thymic alymphoplasia, Lancet 2:1152.

    Article  Google Scholar 

  • Kaplan, S. L., and Grumbach, M. M., 1964, Studies of a human and placental hormone with growth hormone like and prolactin like activities, J. Clin. Endocrinol. Metab. 24:80.

    Article  Google Scholar 

  • Kaplan, S. L., Gurpide, E., Sciarra, J. J., and Grumbach, M. M., 1968, Metabolic clearance rate and production rate of chorionic growth hormone-prolactin in late pregnancy, J. Clin. Endocrinol. Metab. 28:1450.

    Article  Google Scholar 

  • Katz, S. R., Dancis, J., and Levitz, M., 1965, Relative transfer of estriol and its conjugates across the fetal membranes in vitro, Endocrinology 76:722.

    Article  Google Scholar 

  • Kayden, H. J., Dancis, J., and Money, W. L., 1969, Transfer of lipids across the guinea pig placenta, Am. J. Obstet. Gynecol. 104:564.

    Google Scholar 

  • Levitz, M., Condon, G. P., Dancis, J., Goebelsmann, U., Eriksson, G., and Diczfalusy, E., 1967, Transfer of estriol and estriol conjugates across the human placenta perfused in situ at midpreg-nancy, J. Clin. Endocrinol. Metab. 27:1723.

    Article  Google Scholar 

  • Liggins, G. C, and Howie, R. N., 1972, A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants, Pediatrics 50:515.

    Google Scholar 

  • Lipsitz, P. J., 1971, The clinical and biochemical effects of excess magnesium in the newborn, Pediatrics 47:501.

    Google Scholar 

  • Logothetopoulos, J. H., and Scott, R. F., 1956, Active iodide transport across the placenta of the guinea pig, rabbit and rat, J. Physiol. 132:365.

    Google Scholar 

  • Longo, L. D., Power, G. G., and Foster, R. E., II, 1967, Respiratory function of the placenta as determined with carbon monoxide in sheep and dogs, J. Clin. Invest. 46:812.

    Article  Google Scholar 

  • Longo, L. D., Yuen, P., and Gusseck, D. J., 1973, Anaerobic glycogen dependent transport of amino acids by the placenta, Nature (London) 243:531.

    Article  Google Scholar 

  • Lund, C. J., and Kimble, M. S., 1943, Plasma vitamin A and carotene of the newborn infant; with consideration of fetal-maternal relationships, Am. J. Obstet. Gynecol. 46:207.

    Google Scholar 

  • Lust, J., Hagerman, D. D., and Villee, C. A., 1953, The transport of riboflavin by human placenta, J. Clin. Invest. 33:38.

    Article  Google Scholar 

  • MacDonald, P. C., and Siiteri, P. K., 1965, Origin of estrogen in women pregnant with an anencephalic fetus, J. Clin. Invest. 44:465.

    Article  Google Scholar 

  • Mackay, R. B., 1958, Studies of the oxygen consumption of fresh placental tissue from normal and abnormal pregnancies, J. Obstet. Gynaecol. Br. Emp. 65:791.

    Article  Google Scholar 

  • Mansour, M. M., Schillert, A. R., and Glasser, S. R., 1972, Mechanism of placental iron transfer in the rat, Am. J. Physiol. 222:1628.

    Google Scholar 

  • Meschia, G., Battaglia, F. C., and Bruns, P. D., 1967, Theoretical and experimental study of transplacen-tal diffusion, J. Appl. Physiol. 22:1171.

    Google Scholar 

  • Midgley, A. R., Jr., and Pierce, G. B., Jr., 1962, Immunohistochemical localization of human chorionic gonadotropin, J. Exp. Med. 115:289.

    Article  Google Scholar 

  • Mikhail, G., Wiqvist, N., and Diczfalusy, E., 1963, Oestriol metabolism in the previable human foetus, Acta Endocrinol. 42:519.

    Google Scholar 

  • Muchmore, A. V., and Blaese, R. M., 1974, Immunoregulatory effects of human chorionic gonadotropin (HCG), Fed. Proc. 33:750.

    Google Scholar 

  • Nyberg, R., and Westin, B., 1957, The influence of oxygen tension and some drugs on human placental vessels, Acta Physiol. Scand. 39:216.

    Article  Google Scholar 

  • Oakey, R. E., Cawood, M. L., and MacDonald, R. R., 1974, Biochemical and clinical observations in a pregnancy with placental sulfatase and other enzyme deficiencies, Clin. Endocrinol. 3:131.

    Article  Google Scholar 

  • Peer, L. A., Bernhard, W., and Walker, J. C., Jr., 1958, Full-thickness skin exchanges between parents and their children, Am. J. Surg. 95:239.

    Article  Google Scholar 

  • Pitkin, R. M., Connor, W. E., and Lin, D. S., 1972, Cholesterol metabolism and placental transfer in the pregnant rhesus monkey, J. Clin. Invest. 51:2584.

    Article  Google Scholar 

  • Popjak, G., 1954, The origin of fetal lipids, Cold Spring Harbor Symp. Quant. Biol. 19:200.

    Article  Google Scholar 

  • Pulkinnen, M. O. L., 1961, Arylsulfatase and the hydrolysis of some steroid sulfates in developing organisms and placenta, Acta Physiol. Scand. 52(Suppl. 180): 1–92.

    Article  Google Scholar 

  • Raiha, N., 1959, On the placental transfer of vitamin C. An experimental study on guinea pigs and human subjects, Acta Physiol. Scand. 45(Suppl. 155): 1.

    Google Scholar 

  • Rogers, B. O., Raisbeck, A. P., Ballantyne, D. L., Jr., and Converse, J. M., 1960, The genetics of skin homografting in rats between brothers, sisters, parents and grandparents, Trans. Int. Soc. Plastic Surg., Second Congr., pp. 421–436, Livingstone, London.

    Google Scholar 

  • Rosenfeld, C. R., Morris, F. H., Battaglia, F. C, Makowski, E. L., and Meschia, G., 1976, Effect of estradiol-17β on blood flow to reproductive and non reproductive tissues in pregnant ewes, Am. J. Obstet. Gynecol. 124:618.

    Google Scholar 

  • Rosso, P., 1975, Maternal malnutrition and placental transfer of α-aminoisobutyric acid in the rat, Science 187:648.

    Article  Google Scholar 

  • Roughton, F. J. W., 1954, Respiratory functions of blood, in: Respiration Physiology in Aviation (W. M. Boothby, ed), pp. 51–102, Air University USAF School of Aviation Medicine, Randolph Field, Texas.

    Google Scholar 

  • Sakurai, T., Takagi, H., and Hisoya, N., 1969, Metabolic pathways of glucose in human placenta: Changes with gestation and with added 17ß-estradiol, Am. J. Obstet. Gynecol. 105:1044.

    Google Scholar 

  • Schenker, S., Dawber, N. H., and Schmid, R., 1964, Bilirubin metabolism in the fetus, J. Clin. Invest. 43:32.

    Article  Google Scholar 

  • Schiff, R. J., Mercier, D., and Buckley, R. H., 1974, Effects of gestational hormones on human lymphocyte responses in vitro, Fed. Proc. 33(Pt. 1):749.

    Google Scholar 

  • Schneider, H., and Dancis, J., 1974, Amino acid transport in human placental slices, Am. J. Obstet. Gynecol. 120:1092.

    Google Scholar 

  • Schneider, H., Panigel, M., and Dancis, J., 1969, Informal comments on perfusion studies, in: Transactions of the Fifth Rochester Trophoblast Conference (C. J. Lund and J. W. Choate, eds.), pp. 189–196, University of Rochester School of Medicine and Dentistry, Rochester, New York.

    Google Scholar 

  • Schroder, J., 1974a, Fetal leucocytes in the maternal circulation after delivery. I. Cytological aspects, Transplantation 17:346.

    Article  Google Scholar 

  • Schroder, J., 191 Ab, Passage of leucocytes from mother to fetus, Scand. J. Immunol. 3:369.

    Google Scholar 

  • Sdenkow, H. A., Saxena, B. N., Daria, C. L., and Emerson, K., Jr., 1969, Measurement and pathophys-iologic significance of human placental lactogen, in: Foeto-Placental Unit (A. Peale and C. Finzi, eds.), p. 340, Exerpta Medica, Amsterdam.

    Google Scholar 

  • Sherwood, L. M., 1971, A comparison of the structure and function of human placental lactogen and human growth hormone, Proceedings Second International Symposium on Growth Hormone, Milan.

    Google Scholar 

  • Siiteri, P. K., and MacDonald, P. C, 1963, The utilization of circulating dehydroisoandrosteronesulfate for estrogen synthesis during human pregnancy, Steriods 7:713.

    Article  Google Scholar 

  • Siiteri, P. K., and MacDonald, P. C, 1966, Placental estrogen biosynthesis during human pregnancy, J. Clin. Endocrinol. Metab. 26:571.

    Article  Google Scholar 

  • Simmons, R. L., and Rüssel, P. S., 1963, Antigenicity of mouse trophoblast, Ann. N.Y. Acad. Sci. 99:717.

    Article  Google Scholar 

  • Slobody, L. B., Willner, M. M., and Mestern, J., 1949, Comparison of vitamin B1 levels in mothers and their newborn infants, Am. J. Dis. Child 77:736.

    Google Scholar 

  • Solomon, S., and Fuchs, F., 1972, Progesterone and related neutral steroids, in: Endocrinology of Pregnancy (F. Fuchs and A. Klopper, eds.), pp. 66–100, Harper & Row, New York.

    Google Scholar 

  • Stegink, L. D., Pitkin, R., Reynolds, W. A., Filer, L. J., Boaz, D. P., and Brummel, M. C, 1975, Placental transfer of glutamate and its metabolites in the primate, Am. J. Obstet. Gynecol. 122:70.

    Google Scholar 

  • Sternberg, J., and Pascoe-Dawson, E., 1959, Metabolic studies in artherosclerosis. I: Metabolic pathway of 14C labelled alphatocopherol, Can. Med. Assoc. J. 80:266.

    Google Scholar 

  • Straumfjord, J. V., and Quaife, M. L., 1946, Vitamin E levels in maternal and fetal blood plasma, Proc. Soc. Exp. Biol. Med. 61:369.

    Google Scholar 

  • Taylor, J. D., Millar, G. J., and Wood, R. J., 1957, A comparison of the concentration of 14C in the tissues of pregnant and nonpregnant female rats following the intravenous administration of vitamin K1 14C and vitamin K3-14C, Can. J. Biochem. Physiol 35:691.

    Article  Google Scholar 

  • Taylor, T., Courts, J. R. T., and Macnaughton, M. C, 1974, Human fetal synthesis of testosterone from perfused progesterone, J. Endocrinol. 60:321.

    Article  Google Scholar 

  • Terry, C. W., Terry, B. E., and Davies, J., 1960, Transfer of zinc across the placenta and fetal membranes of the rabbit, Am. J. Physiol. 198:303.

    Google Scholar 

  • Thomas, L., Douglas, G. W., and Carr, M. C., 1959, The continual migration of syncytial trophoblasts into the maternal circulation, Trans. Assoc. Am. Phys. 72:140.

    Google Scholar 

  • Tulchinsky, D., and Hobel, C. J., 1973, Plasma human chorionic gonadotropin, estrone, estradiol, estriol, progesterone and 17α-hydroxyprogesterone in human pregnancy, Am. J. Obstet. Gynecol. 117:884.

    Google Scholar 

  • Vaitukaitis, J. L., and Ross, G. T., 1973, Recent advances in evaluation of gonadotropic hormones, Annu. Rev. Med. 24:295.

    Article  Google Scholar 

  • Van Duyne, C. M., Havel, R. J., and Felts, J. M., 1962, Placental transfer of palmitic acid-l-14C in rabbits, Am. J. Obstet. Gynecol. 84:1069.

    Google Scholar 

  • Van Hall, E. V., Vaitukaitis, J. L., Ross, G. T., Hickman, J. W., and Ashwell, G., 1971, Immunological and biological activity of HCG following progressive desialylation, Endocrinology 88:456.

    Article  Google Scholar 

  • Van Slyke, D. D., and Meyer, G. M., 1913, The fate of protein digestion products in the body. HI. The absorption of amino acids from the blood by the tissues, J. Biol. Chem. 16:197.

    Google Scholar 

  • Villee, C.A., 1953a, Regulation of blood glucose in the human fetus, J. Appl. Physiol. 5:437.

    Google Scholar 

  • Villee, C. A., 1953b, The metabolism of human placenta in vitro, J. Biol. Chem. 205:113.

    Google Scholar 

  • Webber, W. A., and Cairns, J. A., 1968, A comparison of the efflux rates of AEB from kidney cortex slices of mature and newborn rats, Can. J. Physiol. Pharmacol. 46:765.

    Article  Google Scholar 

  • Williams, D. J., 1971, Abnormalities of the genito-urinary system, in: Congenital Abnormalities in Infancy (A. P. Norman, ed.), p. 199, Blackwell, Oxford.

    Google Scholar 

  • Wynn, R. H., 1973, Fine structure of the placenta, in: Handbook of Physiology, Section 7: Endocrinology, Vol. II, Female Reproductive System, Part 2 (R. O. Greep, ed.), p. 261, American Physiological Society, Washington.

    Google Scholar 

  • Yen, S. S. C, Llerena, O., Little, B., and Pearson, O. H., 1968, Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man, J. Clin. Endocrinol. Metab. 28:1763.

    Article  Google Scholar 

  • Young, B. K., Jirku, H., Slyper, A. J., Levitz, M., Kelley, W. G., and Yaverbaum, S., 1974, Estriol conjugates in amniotic fluid of normal and Rh-isoimmunized patients, Clin. Endocrinol. Metab. 39:842.

    Article  Google Scholar 

  • Young, M., and Prenton, M. A., 1969, Maternal and fetal plasma amino acid concentrations during gestation and in retarded fetal growth, J. Obstet. Gynaecol. Brit. Commonw. 76:333.

    Article  Google Scholar 

  • Young, M., and Widdowson, E. M., 1975, The influence of diet deficient in energy or in protein, on conceptus weight, and the placental transfer of a non-metabolisable amino acid in the guinea pig, Biol. Neonat. 27:184.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Plenum Press, New York

About this chapter

Cite this chapter

Dancis, J., Schneider, H. (1978). Physiology of the Placenta. In: Falkner, F., Tanner, J.M. (eds) Principles and Prenatal Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0814-0_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-0814-0_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0816-4

  • Online ISBN: 978-1-4684-0814-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics