Abstract
Several important discoveries of the past few decades have launched a renaissance of research into basophil and mast cell function. These include the discovery of IgE and its affinity for basophils and mast cells and the demonstration of the ability of these cells to elaborate and release not only histamine but also a variety of lowmolecular-weight mediators of immediate hypersensitivity. Moreover, the application of modern methods of tissue fixation and processing has permitted confident identification of basophils and mast cells with both the light and electron microscopes in diverse experimental and clinical situations, and has clearly implicated these cells in a variety of delayed-onset immunological phenomena where their participation had been entirely unexpected.
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Galli, S.J., Dvorak, H.F. (1979). Basophils and Mast Cells: Structure, Function, and Role in Hypersensitivity. In: Gupta, S., Good, R.A. (eds) Cellular, Molecular, and Clinical Aspects of Allergic Disorders. Comprehensive Immunology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0988-8_1
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