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Monoclonal Antibodies to Embryonic Neurons

Cell-Specific Markers for Chick Ciliary Ganglion

  • Chapter
Neuronal Development

Part of the book series: Current Topics in Neurobiology ((CTNB))

Abstract

Both genetic and epigenetic events are involved in the generation of precise connections in the nervous system. Vast numbers of individual interactions between single neurons and their microenvironments contribute to the formation of complex neuronal pathways. Environmental cues may come to a developing neuron from many different sources, but there are at least three for which there is good experimental evidence: (1) the insoluble intercellular matrix or substratum consisting of collagens, glycosaminoglycans, fibronectin, etc.1; (2) soluble diffusible factors (neurotrophic factors, growth factors, hormones)2; and (3) the cell surfaces of other neuronal and nonneuronal cells with which a developing neuron comes in contact.3 The cell surface of the target tissue or material associated with it such as the basal lamina probably serves to trigger the formation of the synapse4 and, at least in amphibians,5 its specific regeneration.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, University of Michigan Medical School, Neuroscience Program, Ann Arbor, MI, 48109, USA

    Kate F. Barald

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  1. Kate F. Barald
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Editors and Affiliations

  1. University of California, San Diego, La Jolla, California, USA

    Nicholas C. Spitzer

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© 1982 Plenum Press, New York

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Barald, K.F. (1982). Monoclonal Antibodies to Embryonic Neurons. In: Spitzer, N.C. (eds) Neuronal Development. Current Topics in Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1131-7_3

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  • DOI: https://doi.org/10.1007/978-1-4684-1131-7_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1133-1

  • Online ISBN: 978-1-4684-1131-7

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