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Ontogeny of Human Plasma Proteins: Detection of the Onset and Site of Synthesis Using Genetic Markers and in Vitro Cultures

  • Chapter
Structure and Function of Plasma Proteins

Abstract

The present renewed interest in the fetal proteins derives from their relation to certain biochemical changes that occur in some forms of cancer and other diseases, in which malignant transformation and tissue regeneration may lead to the derepression of genes otherwise active during the early stages of development.1–8 In recent years, fetal plasma and tissue antigens associated with tumor antigens have also been described as “phase-specific antigens” (PSA) to stress that they are produced mainly at certain stages of development and, probably, cell cycle.2,3

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Authors and Affiliations

  1. Paediatric Research Unit, Guy’s Hospital Medical School, London, UK

    Matteo Adinolfi & Anna Adinolfi

  2. Istituto Internazionale di Genetica e Biofisica, Naples, Italy

    Matteo Adinolfi & Anna Adinolfi

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  1. Matteo Adinolfi
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  1. Clinical Research Centre, Watford Road, Harrow, Middlesex, UK

    A. C. Allison

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Adinolfi, M., Adinolfi, A. (1976). Ontogeny of Human Plasma Proteins: Detection of the Onset and Site of Synthesis Using Genetic Markers and in Vitro Cultures. In: Allison, A.C. (eds) Structure and Function of Plasma Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2679-3_1

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