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Biotransformation of Ampicillin, Amoxicillin, and Oxacillin in Healthy Subjects and in Patients with Bacteriuria

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Pharmacology of Antibiotics

Part of the book series: Chemotherapy ((CT,volume 4))

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Abstract

Papers on human metabolism of penicillins are surprisingly rare. Human metabolites, described up to now, are the following: penicilloic acid (l,2,4,5,11,15 and others), 6-APA (2,3), p-hydroxy-phenoxy-acetaldehyd (7,8) and some non identified, active metabolites of several penicillins (9), All these studies were performed — by microbiological, chemical or isotopic methods — on healthy volunteers.

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References

  1. Birner J.: J. Pharm. Sci. 59. 757. 1970.

    Article  PubMed  CAS  Google Scholar 

  2. Cole M. et al: Antimicrob. Agents Chemother. 463. 1973.

    Google Scholar 

  3. English, A.R. et al (Proc. Soc. Exp. Biol. Med. 104. 405. l960.

    Google Scholar 

  4. Hellstrom, K. et al: J. Clin. Pharmacol. Ther. 16. 826. 1974.

    CAS  Google Scholar 

  5. Hellstrom, K. et al: Eur. J. Clin. Pharmacol. 7. 125. 1974.

    Article  PubMed  CAS  Google Scholar 

  6. Holm, K.A.: Anal. Chem. 44. 795. 1972.

    Article  PubMed  CAS  Google Scholar 

  7. Murakawa, T. et al.: J. Antibiot. 25. 421.1972.

    Article  PubMed  CAS  Google Scholar 

  8. Nishida, M. et al: J. Antibiot. 24. 641. 1972.

    Article  Google Scholar 

  9. Rolinson, G.N., Batchelor, R.F.: Antimicrob. Agents Chemother. 654. 1962.

    Google Scholar 

  10. Smith, J.W.G. et al: Analyst. 92. 247. 1967.

    Article  PubMed  CAS  Google Scholar 

  11. Swann, A.: On the metabolism and absorption of some penicillins in man, Ed: Dept. Med. Clin. Pharm. Karolinska Inst. Stockholm, 1974.

    Google Scholar 

  12. Thomas, R.: Nature, 191. 1161. 1961.

    Article  PubMed  CAS  Google Scholar 

  13. Vanderhaege, H.: Nature, 200. 891. 1963.

    Article  Google Scholar 

  14. Van Harken, D.R. et al: Pharmacologist, 12. 220. 1970.

    Google Scholar 

  15. Walkenstein, S.S. et al: Antibiot. Chemother. 4. 1245. 1954.

    CAS  Google Scholar 

  16. Yasuda, T. Shmada, S.: J. Antibiot, 24.290. 1971.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Medicine and Clinical Pharmacology, Municipal Hospital Peterfy, Budapest, Hungary

    Hedvig Graberm, T. Perenyi, Magda Arr & E. Ludwig

Authors
  1. Hedvig Graberm
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  2. T. Perenyi
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  3. Magda Arr
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  4. E. Ludwig
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Editor information

Editors and Affiliations

  1. The London Hospital Medical College, London, UK

    J. D. Williams

  2. East Birmingham Hospital, Birmingham, UK

    A. M. Geddes

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© 1976 Plenum Press, New York

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Graberm, H., Perenyi, T., Arr, M., Ludwig, E. (1976). Biotransformation of Ampicillin, Amoxicillin, and Oxacillin in Healthy Subjects and in Patients with Bacteriuria. In: Williams, J.D., Geddes, A.M. (eds) Pharmacology of Antibiotics. Chemotherapy, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3123-0_30

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  • DOI: https://doi.org/10.1007/978-1-4684-3123-0_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3125-4

  • Online ISBN: 978-1-4684-3123-0

  • eBook Packages: Springer Book Archive

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