Summary
The lipid-soluble methoxymethyl ester of hetacillin was found to penetrate well into the prostatic fluid of dogs. The prostatic fluid ampicillin concentrations following intravenous infusion of the ester were approximately 15 times higher than following intravenous infusion of ampicillin in equivalent amounts and were approximately 1/2 of the simultaneous blood concentrations. The bactericidal effect of the prostatic fluid following hetacillin ester administration is demonstrated in vitro.
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References
Bristol Laboratories, Syracuse, New York. 1975. Inform. Manual.
Meares, E. M. and Stamey, T. A. (1968) Investigative Urology 5, 492.
Winningham, D. G., Nemoy, N. J. and Stamey, T. A. (1968). Nature 219, 139.
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© 1976 Plenum Press, New York
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Kjaer, T.B., Madsen, P.O. (1976). The Excretion of Hetacillin Methoxymethyl Ester (BL-P1761) into the Prostatic Fluid of the Dog. In: Williams, J.D., Geddes, A.M. (eds) Pharmacology of Antibiotics. Chemotherapy, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3123-0_34
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DOI: https://doi.org/10.1007/978-1-4684-3123-0_34
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3125-4
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