Abstract
Administration of FSH to immature rats results in a rapid stimulation of testicular RNA and protein synthesis (1–5). Although enhancement of nuclear RNA synthesis clearly precedes the effects on protein synthesis, little information is available on the sequence of events which occur in FSH target cells prior to stimulation of the transcription process. The bulk of available evidence suggests that entry into the target cell is not prerequisite for many of the actions of peptide hormones (6–9). Rather the surface of target cells have been shown to possess binding sites specific for the effective hormone (10–13). In many instances it has been possible to correlate the cellular attachment of peptide hormones with an activation of membrane-bound adenylate cyclase (10–12, 14–16). The resulting cAMP then serves as an intracellular mediator of hormone action.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Means, A.R., and Hall, P.F., Endocrinology, 81: 1151–ll60, 1967.
Means, A.R., and Hall, P.F., Biochemistry, 8: 4293–4298, 1969.
Means, A.R., and Hall, P.F., Cytobios, 3: 17–24, 1971.
Means, A.R., Adv. Exp. Med. Biol., 10: 301–313, 1970.
Means, A.R., Endocrinology, 89: 981–989, 1971.
Schimmer, B.P., Ueda, K., and Sato, G.H., Biochem. Biophys. Res. Commun., 32: 806–810, 1968.
Pastan, I., Roth, J., and Macchia, V., Proc. Natl. Acad. Sci. U.S.A., 56: 1802–1809, 1966.
Cuatrecasas, P., Proc. Natl. Acad. Sci. U.S.A., 63: 450-457, 1969.
Oka, T., and Topper, Y. J., Proc. Natl. Acad. Sci. U.S.A., 68: 2066–2068, 1971.
Pohl, S.L., Birnbaumer, L., and Rodbell, M., J. Biol. Chem., 246849–1856, 1971.
Cuatrecasas, P., J. Biol. Chem., 246: 7265–7274, 1971.
Freychet, P., Roth, J., and Neville, D.M., Proc. Natl. Acad. Sci. U.S.A., 68: 1833–1837, 1971.
Means, A.R., and Vaitukaitis, J., Endocrinology, 90 39–46, 1971.
Robison, G.A., Butcher, R.W., and Sutherland, E.W., Ann. Rev. Biochem., 37: 149–174, 1968.
Wolff, J., and Jones, A.B., J. Biol. Chem., 246: 3939–3947, 1971.
Dufau, M.L., Catt, K.J., and Tsuruhara, T., Biochim. Biophys. Acta, 252: 574–579, 1971.
Murad, F., Strauch, S., and Vaughn, M., Biochim. Biophys. Acta, 177: 591–598, 1969.
Kuehl, F.A., Patanelli, D.J., Tarnoff, J., and Humes, J.S., Biol. Reprod., 2: 154-163, 1970.
Dorrington, J.H., Vernon, R.G., and Fritz, I.B., Biochem. Biophys. Res. Commun., 46: 1523–1528, 1972.
Swerdloff, R.S., Walsh, P.C., Jacobs, P.C., and O’Dell, W.D., Endocrinology, 88: 120–128, 1971.
Ojeda, S.R., and Ramirez, V.D., Endocrinology, 90: 466–472, 1972.
Mori, K.F., Endocrinology, 85: 330–336, 1969.
Vaitukaitis, J.L., and Ross, G.T., J. Clin. Endocr. Metab., 33: 308–311, 1971.
Morell, A.G., Gregoriadis, G., Scheinberg, I.H., Hickman, J., and Ashwell, G., J. Biol. Chem., 246: l46l–l467, 1971.
Vaitukaitis, J.L., Sherins, R., Ross, G.T., Hickman, J., and Ashwell, G., Endocrinology, 89: 1356–1358, 1971.
Christensen, A.K., and Mason, N.R., Endocrinology, 76 646–656, 1965.
Neville, D.M., Biochim. Biophys. Acta, 154 : 540–552, 1968.
Rodbell, M., Krans, H.M.J., Pohl, S.L., and Birnbaumer, L., J. Biol. Chem., 246 : 1861–1871, 1971.
Gilman, A. G., Proc. Natl. Acad. Sci. U.S.A., 67: 305–312, 1970.
Lowry, O.N., Rosebrough, N.J., Farr, A.L., and Randall, R.J., J. Biol. Chem., 193: 265–275, 1951..
Shen, L.C., Villar-Palasi, C., and Larner, J., Physiol. Chem. Phys., 2: 536–544, 1970.
Shotz, L., and Marinetti, G.V., Biochem. Biophys. Res. Commun., 45: 51–56, 1971.
Soderling, T., Corbin, J.D., and Park, C.R., J. Biol. Chem., in press, 1972.
Corbin, J.D., Soderling, T., and Park, C.R., J. Biol. Chem., in press , 1972.
Dufau, M.L., Catt, K.J., and Tsuruhara, T., Proc. Natl. Acad. Sci. U.S.A. (in press).
Mills, N.C., and Means, A.R., Endocrinology91: 147–156, 1972.
Means, A.R., in Velardo, J.T., and Kasprow. B.D. (eds.): Currents in Reproductive Biology (in press).
Huckins, C. in Velardo, J.T., and Kasprow, B.A. (eds.): Currents in Reproductive Biology (in press).
Dym, M., and Fawcett, D.W., Biol. Reprod., 3: 308–326, 1970.
Present Address of the Author: Department of Cell Biology, Baylor College of Medicine, Houston, Texas
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Plenum Press, New York
About this chapter
Cite this chapter
Means, A.R. (1973). Specific Interaction of 3H-FSH with Rat Testis Binding Sites. In: O’Malley, B.W., Means, A.R. (eds) Receptors for Reproductive Hormones. Advances in Experimental Medicine and Biology, vol 36. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3237-4_20
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3237-4_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3239-8
Online ISBN: 978-1-4684-3237-4
eBook Packages: Springer Book Archive