Abstract
The bone marrow origin of monocytes has been proven, and it is widely accepted that, in vivo, monocytes are the antecedents of the macrophages occurring in inflammatory processes (16). Under in vitro conditions too, monocytes can differentiate into macrophages undergoing morphologically, cytochemically, and biochemically detectable changes similar to those found in vivo (9). Although it has been repeatedly stressed that tissue macrophages, both free and fixed, also derive from blood monocytes (17), this assumption has not been definitely proven. In fact, the study of the fate of blood monocytes in the tissues has been seriously hampered by the lack of reliable criteria for the identification of monocyte-derived macrophages and tissue macrophages. Recently (12), characteristic differences were found in the distribution and nature of perioxidatic (PO) activity between monocytes on the one hand and tissue macrophages, such as those in the peritoneal cavity and liver, on the other. Evidence was also obtained that monocyte-derived macrophages can retain the PO-activity of the monocytes and thus could be distinguished from the resident macrophages (10). The conclusion was drawn that two types of macrophages exist: exudate and resident macrophages, the former being directly derived from monocytes. To verify this conclusion, monocytes isolated from the peripheral blood of normal mice were cultivated in intraperitoneally installed diffusion chambers. In addition, macrophages from the unstimulated peritoneal cavities of mice as well as monocytes in saline-induced peritoneal exudates were studied with respect to the distribution of PO-activity.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Amos, D.B., Transplantation of Tissues and Cells (Ed. R.E. Billingham and W.K. Silver ), Wistar Institute, Philadelphia (1961) 69.
Benestad, H.B., Scand. J. Haematol., 7 (1970) 279.
Benestad, H.B., Rytömaa, T. and Kiviniemi, K., Cell Tiss. Kin., 6 (1973) 147.
Bennett, B., Old, L.J. and Boyce, E.A., Transplantation, 2 (1964) 183.
Blanden, R.V., J. Reticuloendothel. Soc., 5 (1968) 179.
Boyum, A., Tiss. Antigens, 4 (1974) 269.
Boyum, A. and Breivik, H., Cell Tiss. Kin., 6 (1973) 101.
Carr, I., Z. Zellforsch., 80 (1967) 534.
Cline, M.J., Formation and Destruction of Blood Cells (Ed. T.J. Greenwalt and G.A. Jamieson ), J.B. Lippincott, Philadelphia (1970) 222.
Daems, W.Th. and Brederoo, P., Z. Zellforsch., 144 (1973) 247.
Daems, W.Th., Wisse, E. and Brederoo, P., Lysosomes in Biology and Pathology (Ed. J.T. Dingle and H.B. Fell), North-Holland, Amsterdam, Vol. 1 (1969) 64.
Daems, W.Th., Wisse, E., Brederoo, P. and Emeis, J.J., Mononuclear Phagocytes in Infection, Immunity and Pathology (Ed. R. van Furth ), Blackwell, Oxford (1975) 57.
Feldman, J.D., Tubergen, D.G., Pollock, E.M. and Unanue, E.R., Cell Immunol., 5 (1972) 325.
Felix, M.D. and Dalton, A.J., J. Natl. Cancer Inst., 16 (1956) 415.
Fukuda, T., Virchows Archiv Abt. B. Cell Pathol., 16 (1974) 249.
van Furth, R., Ed., Mononuclear Phagocytes, Blackwell, Oxford (1970).
van Furth, R., Cohn, Z.A., Hirsch, J.G., Humphrey, J.H., Spector, W.G. and Langevoort, H.L., Bull. Wld. Hlth. Org., 46 (1972) 845.
Golde, D.W., Finley, T.N. and Cline, M.J., New Eng. J. Med., 290 (1974) 875.
Hibbs, J.B., Lambert, L.H. and Remington, J.S., Nature (New Biol.), 235 (1972) 48.
Hirsch, J.G. and Fedorko, M.E., Mononuclear Phagocytes (Ed. R. van Furth ), Blackwell, Oxford (1970) 7.
Hjortdal, O. and Rasmussen, P., Acta Anat., 72 (1969) 304.
Hoefsmit, E.Ch.M., Mononuclear Phagocytes in Immunity, Infection and Pathology (Ed. R. van Furth ), Blackwell, Oxford (1975) 129.
LeJeune, F. and Evans, R., Eur. J. Cancer, 8 (1972) 549.
Libansky, J., Blut, 13 (1966) 20.
Lin, H., J. Cell Physiol., 84 (1974) 159.
Lin, H. and Steward, C.C., J. Cell Physiol., 83 (1974) 369.
Mackaness, G.B., J. Exp. Med., 112 (1960) 35.
McIntyre, J., Rowley, D. and Jenkin, C.R., Aust. J. Exp. Med., 45 (1967) 675.
Miller, Th.E., Infect. Immun., 3 (1971) 390.
Montfort, I. and Pérez-Tamayo, R., Proc. Soc. Exp. Biol. Med., 138 (1971) 204.
North, R.J., J. Exp. Med., 132 (1970) 521.
Novikoff, A.B. and Novikoff, Ph.M., J. Histochem. Cytochem., 21 (1973) 963.
Poelmann, R., J. Anat., 119 (1975) 421.
Poelmann, R. and Vermeij-Keers, C., personal communication (1975).
Rhee, H.J. van der, personal communication (1975).
Rice, S.G. and Fishman, M., Cell. Immunol., 11 (1974) 130.
Shelton, E. and Rice, M.E., Am. J. Anat., 105 (1959) 281.
Simmons, S.R. and Karnovsky, M.L., J. Exp. Med., 138 (1973) 44.
Walker, W.S., Immunology, 26 (1974) 1025.
Widmann, J.J., Cotran, R.S. and Fahimi, H.D., J. Cell Biol., 52 (1972) 159.
Wisse, E., J. Ultrastruct. Res., 46 (1974) 393.
Wisse, E., J. Ultrastruct. Res., 46 (1974) 499.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Daems, W.T., Koerten, H.K., Soranzo, M.R. (1976). Differences between Monocyte-Derived and Tissue Macrophages. In: Reichard, S.M., Escobar, M.R., Friedman, H. (eds) The Reticuloendothelial System in Health and Disease. Advances in Experimental Medicine and Biology, vol 73. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3297-8_3
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3297-8_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3299-2
Online ISBN: 978-1-4684-3297-8
eBook Packages: Springer Book Archive