Abstract
During the metabolism of ethanol, albumin and urea synthesis are inhibited in the liver and it has been shown in the isolated perfused rabbit liver that the combination of fasting plus ethanol is more inhibitory to the protein synthesizing mechanism than either stress alone (1-3). In addition, specific amino acids are capable of reversing both the effects of fasting and of ethanol when these two types of stresses are supplied separately (4). One of these amino acids is ornithine, an amino acid not incorporated into protein. However, ornithine is the percursor of the polyamines, and these substances have been shown to play important roles in cellular regeneration (5-9). Since the mechanism of action of ethanol metabolism in inhibiting protein synthesis is not known, the present studies were undertaken to evaluate the effects of acetaldehyde on albumin synthesis and to determine if the amino acids and spermine play similar roles during ethanol infusions or in fasting states (4).
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References
Jeejeebhoy KN, Phillips MJ, Bruce-Robertson A, et al: The acute effect of ethanol on albumin, fibrinogen, and transferrin synthesis in the rat. Biochem J 126: 1111–1126, 1972
Rothschild MA, Oratz M, Schreiber SS: Alcohol, amino acids, and albumin synthesis studied in vivo, in the perfused liver, and on amino acid incorporation by hepatic microsomes. J Clin Invest 47;2591–2599, 1968
Perin A, Scalabrino G, Sessa A, Arnaboldi A: In vitro inhibition of protein synthesis in rat liver as a consequence of ethanol metabolism. Biochimica 366: 101–108, 1974
Oratz M, Rothschild MA, Schreiber SS: Alcohol inhibition of albumin synthesis reversed by arginine and spermine. Gastroent J 71:123–127, 1976
Russell DH: Putrescine and spermidine biosynthesis in growth and development. Ann NY Acad Sei 171:772–782. 1970
Raina A, Janne J: Polyamines and the accumulation of RNA in mammalian systems. Fed Proc 29:1568–1574, 1970
Khawaja JA: Interactions of ribosomes and ribosomal subpartides with endoplasmic reticulum membranes in vitro: effect of spermine and magnesium. Biochem Biophys Acta 254:117–128, 1971
Atkins JF, Lewis JB, Anderson CW, Gesteland RF: Enhanced differential synthesis of proteins in a mammalian cell-free system by addition of polyamines. Bio Chem J 250:5688–5695, 1975
Igarashi K, Yabuki M, Yoshioka Y, Eguchi K, Hirose S: Mechanism of stimulation of polyphenylalanine synthesis by spermidine. Biochem Biophys Comm 75:163–171, 1977
Oratz M, Rothschild MA, Schreiber SS: Alcohol, amino acids, and albumin synthesis. III. Effects of ethanol, acetaldehyde, and 4-methylpyrazole. Gastroent. 74:672–676, 1978.
Swick RW; Measurement of protein turnover is rat liver. J. Clin Invest 234:751–764, 1958
Reeve EB, Pearson JR, Martz DC: Plasma proten synthesis in the rat liver: method for measurement of albumin formulation in vivo. Science 139:914–916, 1968
McFarlane AS: Measurement of synthesis rates of liver-produced plasma proteins. Biochem J 89: 277–290. 1963
Schreiber SS, Briden K, Oratz M, et al: Ethanol, acetaldehyde and myocardial protein synthesis. J Clin Invest 51: 2820–2826, 1972
Buttner H: Aldehyd- und Alkoholdehydrogenase Activitat in Leber und Niere der Ratte. Biochem Z 341: 300–314, 1965
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© 1980 Plenum Press, New York
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Rothschild, M.A., Oratz, M., Schreiber, S.S. (1980). Ethanol Effects on Albumin Sythesis. In: Begleiter, H. (eds) Biological Effects of Alcohol. Advances in Experimental Medicine and Biology, vol 126. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3632-7_28
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DOI: https://doi.org/10.1007/978-1-4684-3632-7_28
Publisher Name: Springer, Boston, MA
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