Abstract
During the past several years, our laboratory has sought compounds that would antagonize actions of ethanol. This strategy was undertaken not only to study putative amethystic agents (Erickson, 1979), but also to provide information about biological mechanisms by which ethanol alters central nervous system (CNS) function. Thus, if a putative antagonist were found that altered all actions of ethanol, it might be possible to link the effects of ethanol to a single neurobiological mechanism. Furthermore, if the pharmacological actions of the antagonist were well enough defined, predictions could be made concerning specific neural mechanisms intrinsic to specific actions of ethanol. The research described will use this general perspective, and focus on studies that were conducted to examine the effects of thyrotropin-releasing hormone (TRH) against ethanol.
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References
Bassiri, R.M. and Utiger, R.D. The preparation and specificity of antibody to thyrotropin releasing hormone. Endocrinology 90: 722–727 (1972).
Bowers, C.Y., Friesen, H.G., Hwang, P., Guyda, H.J. and Folkes, K. Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide. Biochem. Biophys. Res. Commun. 45: 1033–1041 (1971).
Breese, G.R., Cott, J.M., Cooper, B.R., Prange, A.J., Jr. and Lipton, M.A. Antagonism of ethanol narcosis by thyrotropin releasing hormone. Life Sci. 14: 1053–1063 (1974).
Breese, G.R., Cott, J.M., Cooper, B.R., Prange, A.J., Jr., Lipton, M.A. and Plotnikoff, N.P. Effects of thyrotropin-releasing hormone on the actions of pentobarbital and other centrally acting drugs. J. Pharmacol. Exp. Ther. 193: 11–22 (1975).
Carlsson, A., Engel, J., Strombom, U., Svensson, T.H. and Waldeck, B. Suppression by dopamine agonists of the ethanol-induced stimulation of locomotor activity and brain dopamine synthesis. Naunyn-Schmiedeberg’s Arch. Pharmacol. 283: 117–128 (1978).
Cornford, E.M., Braun, L.D., Crane, P.D. and Oldendorf, W.H. Blood- brain barrier restriction of peptides and the low uptake of enkephalins. Endocrinology 103: 1297–1303 (1978).
Cott, J.M., Breese, G.R., Cooper, B.R., Barlow, T.S. and Prange, A, J., Jr. Investigations into the mechanisms of reduction of ethanol sleep by thyrotropin releasing hormone (TRH). J. Pharmacol. Exp. Ther. 196: 594–604 (1976).
Emerson, C.H., Frohman, L.A., Szabo, M. and Thakkar, I. TRH immuno-reactivity in human urine: Evidence for disassociation from TRH. J. Clin. Endo. Metab. 45: 392–399 (1977).
Erickson, C.K. Requirements for an ideal alcohol antagonist [THIS VOLUME] (1979).
Guillemin, R. Peptides in the brain: The new endocrinology of the neuron. Science 202: 390–401 (1978).
Horita, A., Carino, M.A. and Weick, B.G. Effects of thyrotropin-releasing hormone (TRH) microinjected into various areas of conscious and pentobarbital-pretreated rabbits. Proc. West. Pharmacol. Soc. 19: 212–213 (1978).
Horst, W.D. and Spirt, N. A possible mechanism for the antidepressant activity of thyrotropin releasing hormone. Life Sci. 15: 1073–1082 (1974).
Keller, H.H., Bartholini, G. and Pletscher, A. Enhancement of cerebral noradrenaline turnover by thyrotropin releasing hormone. Nature 248: 528–529 (1974).
Kraemer, G.N., Mueller, R.A., Breese, G.R., Prange, A.J., Jr., Lewis, J.K., Morrison, H. and McKinney, W.T. Thyrotropin releasing hormone: Antagonism of pentobarbital narcosis in the monkey. Pharmacol. Biochem. Behav. 4: 709–712 (1976).
Lundberg, D., Breese, G.R., Mailman, R.B., Frye, G.D. and Mueller, R.A. Depression of some drug-induced in vivo changes in cerebellar guanosine-3’,5’-monophosphate (cGMP) by control of motor and respiratory changes. Mol. Pharmacol., in press (1979).
Mailman, R.B., Frye, G.D., Mueller, R.A. and Breese, G.R. Thyrotropin-releasing hormone reversal of ethanol-induced decreases in cerebellar cGMP. Nature 272: 832–833 (1978).
Mailman, R.B., Frye, G.D., Mueller, R.A. and Breese, G.R. Change in brain guanosine-3’,5’-monophosphate (cGMP) content by thyrotropin releasing hormone. J. Pharmacol. Exp. Ther., in press (1979).
Mailman, R.B., Mueller, R.A., Frye, G.D. and Breese, G.R. Thyrotropin-releasing hormone (TRH) elevates cerebellar cGMP levels. Neurosci. Abstr. 3: 444 (1977).
Mueller, R.A., Lundberg, D., Frye, G.D., Mailman, R.B. and Breese, G.R. Cerebellar cGMP varies with motor function and respiratory gas exchange. Neurosci. Lett., in press (1978).
Plotnikoff, N.P., Prange, A.J., Jr., Breese, G.R. and Anderson, M.S. Enhancement of DOPA activity by a hypothalamic hormone, thyrotropin-releasing hormone, TRH. Science 178: 417–418 (1972).
Prange, A.J., Breese, G.R., Cott, J.M., Martin, B.R., Cooper, B.R., Wilson, I.e. and Plotnikoff, N.P. Thyrotropin-releasing hormone: Antagonism of pentobarbital in rodents. Life Sci. 14: 447–455 (1974).
Redding, T, W. and Schally, A.V. On the half-life of thyrotropin- releasing hormone in rats. Neuroendocrinology 9: 250–256 (1972).
Redos, J.D., Catravas, G, N. and Hunt, W.A. Ethanol-induced depletion of cerebellar guanosine-3’,5’-cyclic monophosphate. Science 193: 58–59 (1976).
Reigle, T.G., Avni, J., Platz, P.A., Schildkraut, J.J. and Plotnikoff, N.P. Norepinephrine metabolism in the rat brain following acute and chronic administration of thyrotropin releasing hormone. Psychopharmacologia 37: 1–6 (1974).
Schally, A.V. Aspects of hypothalamic regulation of the pituitary gland. Science 202:18–28 (1978).
Volicer, L. and Hurter, B.P. Effects of acute and chronic ethanol administration and withdrawal on adenosine-3’,5’-monophosphate and guanosine-3’,5’-monophosphate levels in the rat brain. J. Pharmacol, Exp. Ther. 200: 298–305 (1977).
Yarbrough, G.C. TRH potentiates excitatory actions of acetyl choline on cerebral cortical neurons. Nature 263: 523–524 (1976).
Yarbrough, G.C. Studies on the neuropharmacology of thyrotropin releasing hormone (TRH) and a new TRH analog. Eur. J. Pharmacol. 48: 19–27 (1978).
Youngblood, W.W., Lipton, M.A. and Kizer, J.S. TRH-like immuno- reactivity in urine, serum and extrahypothalamic brain: Non-identity with synthetic [pyroGlu-Hist-Pro-NH2] (TRH). Brain Res. 151: 99–116 (1978).
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Mailman, R.B., Frye, G.D., Mueller, R.A., Breese, G.R. (1980). The Effects of Thyrotropin-Releasing Hormone (TRH) and other Drugs on the Actions of Alcohol. In: Begleiter, H. (eds) Biological Effects of Alcohol. Advances in Experimental Medicine and Biology, vol 126. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3632-7_38
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