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Hybrid Sterility Gene Located in the T/t-H-2 Supergene on Chromosome 17

  • Chapter
Current Trends in Histocompatibility

Abstract

Recent advances in genetic analysis of the major histocompatibility systems of various species and the first successful attempts at molecular dissection of their products contrast with the limited knowledge concerning the biological function of this particular part of the eukaryotic genome. The major histocompatibility system of the mouse, the H-2 system, adjoins closely the T/t genetic complex in chromosome 17. The T/t complex occupies a region of the chromosome 20 times longer than that pertaining to the H-2 system, and controls a variety of vital functions necessary for the development of the organism and survival of the species.

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References

  • Artzt, K., and Bennett, D., 1975, Analogies between embryonic (T/t) antigens and adult major histocompatibility (H-2) antigens, Nature (London) 256:545.

    Article  CAS  Google Scholar 

  • Artzt, K., and Bennett, D., 1977, Serological analysis of sperm of antigenically cross-reacting T/t haplotypes and their recombinants, Immunogenetics 5:97.

    Article  Google Scholar 

  • Artzt, K., Bennett, D., and Jacob, F., 1974, Primitive teratocarcinoma cells express a differentiation antigen specified by a gene at the T-locus in the mouse, Proc. Natl. Acad. Sci. U.S.A. 71:811.

    Article  PubMed  CAS  Google Scholar 

  • Artzt, K., Hamburger, L., and Flaherty, L., 1977, H-39, a histocompatibility locus closely linked to the T/t complex, Immunogenetics 5:477.

    Article  Google Scholar 

  • Baranov, V.S., and Dyban, A.P., 1972, Embryonic damage of trisomic offsprings of mice with Robertsonian translocation (centric fusion) T1 Iem, Arch. Anat. Histol. Embryol. 63:67 (in Russian).

    CAS  Google Scholar 

  • Beechey, C.V., and Searle, A.G., 1978, Private communication, Mouse News Lett. 59:20.

    Google Scholar 

  • Bennett, D., 1964, Embryological effects of lethal alleles in the t-region, Science 144:263.

    PubMed  CAS  Google Scholar 

  • Bennett, D., 1975, The T-locus of the mouse: A review, Cell 6:441.

    Article  Google Scholar 

  • Bennett, D., and Dunn, L.C., 1967, Studies of effects of t-alleles in the house mouse on spermatozoa. I. Male sterility effect,J. Reprod. Fertil. 13:421.

    Article  PubMed  CAS  Google Scholar 

  • Bennett, D., Dunn, L.C., and Rynerson, D., 1969, Genetical and embryological comparisons of semilethal t-alleles from wild mouse populations, Genetics 61:411.

    PubMed  CAS  Google Scholar 

  • Bennett, D., Goldberg, E., Dunn, L.C., and Boyse, E.A., 1972, Serological detection of a cell surface antigen specified by the T (Brachyury) mutant gene in the house mouse, Proc. Natl. Acad. Sci. U.S.A. 69:2076.

    Article  PubMed  CAS  Google Scholar 

  • Bennett, D., Dunn, L.C., and Artzt, K., 1976, Genetic change in mutations at the T/t-locus, Genetics 83:361.

    PubMed  CAS  Google Scholar 

  • Bennett, W.I., Gall, A.M., Southward, J.L., and Sidman, R.L., 1971, Abnormal spermioge-nesis in Quaking, a myelin-deficient mutant mouse, Biol. Reprod. 5:30.

    PubMed  CAS  Google Scholar 

  • Bodmer, W.F., 1978, HLA: Asupersupergene, in: Harvey Lectures 1976–1977, pp. 91–138, Academic Press, New York.

    Google Scholar 

  • Boyse, E.A., and Old, L.J., 1969, Some aspects of normal and abnormal cell surface genetics, Annu. Rev. Genet. 3:269.

    Article  Google Scholar 

  • Braden, A.W.H., 1972, T-locus in mice: Segregation distortion and sterility in the male, in: Proceedings of the International Symposium on the Genetics of the Spermatozoon (R.A. Beatty and S. Gluecksohn-Waelsch, eds.), p. 289, Bogtrykkeriet Forum, Copenhagen.

    Google Scholar 

  • Braden, A.W.H., and Gluecksohn-Waelsch, S., 1958, Further studies of the effect of the T-locus in the house mouse on male fertility,J. Exp. Zool. 138:431.

    Article  PubMed  CAS  Google Scholar 

  • Bryson, V., 1944, Spermatogenesis and fertility in Mus musculus as affected by factors at the T locus,J. Morphol. 74:131.

    Article  Google Scholar 

  • Burgos, M.H., and Fawcett, D.W., 1955, Studies on the fine structure of the mammalian testis. I. Differentiation of the spermatids in the cat,J. Biophys. Biochem. Cytol. 1:287.

    Article  PubMed  CAS  Google Scholar 

  • Carter, T.C., Lyon, M.F., and Phillips, R.J.S., 1955, Gene tagged chromosome translocations in eleven stocks of mice,J. Genet. 53:21.

    Article  Google Scholar 

  • Cattanach, B.M., 1978, Crossover suppression in mice heterozygous for tobacco mouse metacentrics, Cytogenet. Cell Genet. 20:264.

    Article  PubMed  CAS  Google Scholar 

  • Dobzhansky, T., 1951, Genetics and the Origin of Species, 3rd ed, Columbia University Press, New York.

    Google Scholar 

  • Dooher, G.B., and Bennett, D., 1974, Abnormal microtubular systems in mouse spermatids associated with a mutant gene at the T-locus,J. Embryol. Exp. Morphol. 32:749.

    PubMed  CAS  Google Scholar 

  • Dooher, G.B., and Bennett, D., 1977, Spermatogenesis and spermatozoa in sterile mice carrying different lethal T/t locus haplotypes: A transmission and scanning electron microscopic study, Biol. Reprod. 17:269.

    Article  PubMed  CAS  Google Scholar 

  • Dunn, L.C., 1964, Abnormalities associated with a chromosome region in the mouse, Science 144:260.

    Article  PubMed  CAS  Google Scholar 

  • Dunn, L.C., and Gluecksohn-Schoenheimer, S., 1950, Repeated mutations in one area of a mouse chromosome, Proc. Natl. Acad. Sci. U.S.A. 36:233.

    Article  PubMed  CAS  Google Scholar 

  • Dunn, L.C., and Morgan, W.C., 1953, Segregation ratios of mutant alleles from wild populations of Mus musculus, Am. Nat. 87:327.

    Google Scholar 

  • Dyban, A.P., and Baranov, V.S., 1978, Cytogenetics of Development in Mammals, Nauka, Moscow (in Russian).

    Google Scholar 

  • Eicher, E.M., and Washburn, L.L., 1978, Assignment of genes to regions of mouse chromosome, Proc. Natl. Acad. Sci. U.S.A. 75:946.

    Article  PubMed  CAS  Google Scholar 

  • Erickson, R.P., 1977, Gene expression of a region of chromosome 17 during murine spermatogenesis, J. Immunogenet.4:353.

    Article  PubMed  CAS  Google Scholar 

  • Erickson, R.P., Gachelin, G., Fellous, M., and Jacob, F., 1977, Absorption analysis of H-2D and K antigens on spermatozoa,J. Immunogenet. 4:47.

    Article  PubMed  CAS  Google Scholar 

  • Erickson, R.P., Lewis, S.E., and Slusser, K.S., 1978, Deletion mapping of the T-complex of chromosome 17 of the mouse, Nature(London) 274:163.

    Article  CAS  Google Scholar 

  • Fawcett, D.W., 1972, Observations on cell differentiation and organelle continuity in spermatogenesis, in: Proceedings of the International Symposium on the Genetics of the Spermatozoon (R.A. Beatty and S. Gluecksohn-Waelsch, eds.), p. 37, Bogtrykkeriet Forum, Copenhagen.

    Google Scholar 

  • Fellous, M., Ericksohn, R.P., Gachelin, G., Dubois, P., and Jacob, F., 1976, The time of appearance of Ia antigens during spermatogenesis in the mouse: Relationship between Ia antigens and H-2, beta-2 microglobulin and F9 antigen, Folia Biol. (Prague) 22:381.

    CAS  Google Scholar 

  • Flaherty, L., 1975, H-33—a histocompatibility locus to the left of the H-2 complex, Immu-nogenetics 2:325.

    Google Scholar 

  • Forejt, J., 1972, Chiasmata and crossing-over in the male mouse (Mus musculus): Suppression of recombination and chiasma frequencies in the ninth linkage group, Folia Biol. (Prague) 18:161.

    CAS  Google Scholar 

  • Forejt, J., 1973, Centromere-T locus distance in the chromosome 17, Mouse News Lett. 49:45.

    Google Scholar 

  • Forejt, J., 1974, Nonrandom association between a specific autosome and the X chromosome in meiosis of the male mouse: Possible consequence of the homologous centromeres separation, Cytogenet. Cell Genet. 13:369.

    Article  Google Scholar 

  • Forejt, J., 1976a, H-2-linked gene involved in modification of fertility of translocation carriers, Folia. Biol. (Prague) 22:53.

    Google Scholar 

  • Forejt, J., 1976b, Spermatogenic failure of translocation heterozygotes affected by H-2-linked gene in mouse, Nature (London) 260:143.

    Article  CAS  Google Scholar 

  • Forejt, J., 1979, Meiotic studies of translocations causing male sterility in the mouse. II. Double heterozygotes for Robertsonian translocations, Cytogenet. Cell Genet. 23:163.

    Article  PubMed  CAS  Google Scholar 

  • Forejt, J., and Gregorova, S., 1977, Meiotic studies of translocations causing male sterility in the mouse. I. Autosomal reciprocal translocations, Cytogenet. Cell Genet. 19:159.

    Article  PubMed  CAS  Google Scholar 

  • Forejt, J., and Ivânyi, P., 1975, Genetic studies of male sterility of hybrids between laboratory and wild mice (Mus musculus L.). Genet. Res. 24:189.

    Article  Google Scholar 

  • Forejt, J., and Lengerovâ, A., 1981, Membrane antigens as markers of cell differentiation and transformation, in: Proc. XIV Int. Congress of Genetics (in press).

    Google Scholar 

  • Forejt, J., Gregorová, S., and Capková, J., 1978, Private communication. Construction of a stock trisomic for T-t complex, Mouse News Lett. 59:55.

    Google Scholar 

  • Gachelin, G., 1978, The cell surface antigens of mouse embryonal carcinoma cells, Biochim. Biophys. Acta 516:27.

    PubMed  CAS  Google Scholar 

  • Gachelin, G., Fellous, M., Guénet, J.L., and Jacob, F., 1976, Developmental expression of an early embryonic antigen common to mouse spermatozoa and cleavage embryos, and to human spermatozoa: Its expression during spermatogenesis, Dev. Biol. 50:310.

    Article  PubMed  CAS  Google Scholar 

  • Gluecksohn-Waelsch, S., and Erickson, R.P., 1970, The T-locus of the mouse: Implications for mechanisms of development, Curr. Top. Dev. Biol. 5:281.

    Article  PubMed  CAS  Google Scholar 

  • Goridis, C., Artzt, K., Wortham, K.A., and Schachner, M., 1978, Brain cell surface antigens on embryonal carocinoma cells, Dev. Biol. 65:238.

    Article  PubMed  CAS  Google Scholar 

  • Gropp, A., 1975, Chromosomal animal model of human disease: Fetal trisomy and developmental failure, in: Teratology (C. Berry and D.E. Posville, eds.), pp. 17–31, Springer-Verlag, Berlin, Heidelberg, New York.

    Chapter  Google Scholar 

  • Gropp, A., Tettenborn, U., and Leonard, A., 1970, Identification of acrocentric chromosomes involved in the formation of “fusion” metacentrics in mice: Proposal for nomenclature of M. poschiavinus metacentrics, Experientia 26:1018.

    Article  PubMed  CAS  Google Scholar 

  • Hammerberg, C., and Klein, J., 1975a, Linkage disequilibrium between H-2 and t complexes in chromosome 17 of the mouse, Nature (London) 258:296.

    Article  CAS  Google Scholar 

  • Hammerberg, C., and Klein, J., 1975b, Linkage relationships of markers on chromosome 17 of the mouse, Genet. Res. 26:203.

    Article  CAS  Google Scholar 

  • Ivânyi, P., and Micková, M., 1971, Further studies on genetic factors in the ninth linkage group influencing reproductive performance in male mice in: Proceedings of the Symposium on Immunogenetics of the H-2 System (A. Lengerová and M. Vojtíšková eds.), pp. 104–119, S. Karger, Basel.

    Google Scholar 

  • Iványi, P., Vojtisková, M., Démant, P., and Micková, M., 1969, Genetic factors in the ninth linkage group influencing reproductive performance in male mice, Folia Biol. (Prague) 15:401.

    Google Scholar 

  • Jacob, F., 1977, Mouse teratocarcinoma and embryonic antigens, Immunol. Rev. 33:3.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, P.A., 1972, Human population cytogenetics, in: Proceedings of the IVth International Congress on Human Genetics, p. 232, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Johnston, P.G., 1968, Male sterility in mice homozygous for the Tw2 allele, Aust. J. Biol. Sci. 21:947.

    PubMed  CAS  Google Scholar 

  • Key, M., and Hollander, W.F., 1972, Thin fur, a recessive mutant of chromosome 17 of the mouse,J. Hered. 63:97.

    PubMed  CAS  Google Scholar 

  • Kierszenbaum, A.L., and Tres, L.L., 1975, Structural and transcriptional features of the mouse spermatid genome,J. Cell. Biol. 65:258.

    Article  PubMed  CAS  Google Scholar 

  • Klein, J., 1971, Cytological identification of the chromosome carrying the IXth linkage group (including H-2) in the house mouse, Proc. Natl. Acad. Sci. U.S.A. 68:1594.

    Article  PubMed  CAS  Google Scholar 

  • Klein, J., 1978, H-2 mutations: Their genetics and effect on immune reactions, Adv. Immmunol. 26:55.

    Article  CAS  Google Scholar 

  • Klein, J., and Hammerberg, C., 1977, The control of differentiation by the T complex, Immunol. Rev. 33:70.

    Article  PubMed  CAS  Google Scholar 

  • Klein, J., and Klein, D., 1972, Position of the translocation break T/2:9/138Ca in linkage group IX of the mouse, Genet. Res. 19:177.

    Article  PubMed  CAS  Google Scholar 

  • Klyde, B.J., 1970, Selection in mice for change in viability of a semilethal genotype at the T locus,J. Hered. 61:39.

    PubMed  CAS  Google Scholar 

  • Koo, G.C., Mittl, L.R., and Boyse, E.A., 1977, Antibody to testicular cells in the serum of normal mice, Immunogenetics 4:213.

    Article  Google Scholar 

  • Králová, J., and Démant, P., 1976, Expression of the H-Y antigen on thymus cells and skin: Differential genetic control linked to K end of H-2, Immunogenetics 3:583.

    Article  Google Scholar 

  • Králová, J., and Lengerová, A., 1979, H-Y antigen: Genetic control of the expression as detected by host-versus-graft popliteal lymph node enlargement assay maps between the T and H-2 complexes,J. Immunogenet. 6:429.

    Article  PubMed  Google Scholar 

  • Kysliková, L., and Forejt, J., 1972, Chiasma frequencies in three inbred strains of mice, Folia Biol. (Prague) 18:216.

    Google Scholar 

  • Lengerová, A., 1977, Membrane Antigens, Gustav Fisher Verlag, Jena.

    Google Scholar 

  • Lewontin, R.C., 1962, Interdeme selection controlling a polymorphism in the house mouse, Am. Nat. 96:65.

    Article  Google Scholar 

  • Lewontin, R.C., 1968, The effect of differential viability on the population dynamics of t alleles ins the house mouse, Evolution 22:262.

    Article  Google Scholar 

  • Lewontin, R.C., 1974, The Genetic Basis of Evolutionary Change, Columbia University Press, New York.

    Google Scholar 

  • Lyon, M.F., 1956, Hereditary hair loss in the tufted mutant of the house mouse,J. Hered. 47:101.

    Google Scholar 

  • Lyon, M.F., and Bechtol, K.B., 1977, Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion, Genet. Res. 30:63.

    Article  PubMed  CAS  Google Scholar 

  • Lyon, M.F., and Glenister, P.H., 1977, Factors affecting the observed number of young resulting from adjacent-2 disjunction in mice carrying a translocation, Genet. Res. 29:83.

    Article  PubMed  CAS  Google Scholar 

  • Lyon, M.F., and Mason, I., 1977, Information on the nature of t-haplotypes from the interaction of mutant haplotypes in male fertility and segregation ratio, Genet. Res. 29:255.

    Article  Google Scholar 

  • Lyon, M.F., and Meredith, R., 1964a, Investigations of the nature of t-alleles in the mouse. I. Genetic analysis of a series of mutants derived from a lethal allele, Heredity 19:301.

    Article  CAS  Google Scholar 

  • Lyon, M.F., and Meredith, R., 1964b, Investigations of the nature of t-alleles in the mouse. II. Genetic analysis of an unusual mutant allele and its derivatives, Heredity 19:313.

    Article  CAS  Google Scholar 

  • Lyon, M.F., and Meredith, R., 1964c, Investigations of the nature of t-alleles in the mouse. III. Short tests of some further mutant alleles, Heredity 19:327.

    Article  CAS  Google Scholar 

  • Lyon, M.F., and Phillips, R.J.S., 1959, Crossing-over in mice heterozygous for t-alleles, Heredity 13:23.

    Article  Google Scholar 

  • Lyon, M.F., and Sayers, I.M., 1977, Private communication, Mouse News Lett. 57:17.

    Google Scholar 

  • Lyon, M.F., Glenister, P.H., and Hawker, S.G., 1972, Do the H-2 and T loci of the mouse have a function in the haploid phase of sperm?, Nature (London) 240:152.

    Article  CAS  Google Scholar 

  • Lyon, M.F., Evans, E.P., Jarvis, S.E., and Sayers, I., 1979, t-Haplotypes of the mouse may involve a change in intercalary DNA, Nature (London) 279:38.

    Article  CAS  Google Scholar 

  • Mayr, E., 1963, Animal Species and Evolution, Harvard University Press, Cambridge, Massachusetts.

    Google Scholar 

  • Miller, O.J., and Miller, D.A., 1975, Cytogenetics of the mouse, Annu. Rev. Genet. 9:285.

    Article  PubMed  CAS  Google Scholar 

  • Monesi, V., 1965, Synthetic activities during spermatogenesis in the mouse: RNA and protein, Exp. Cell Res. 39:197.

    Article  PubMed  CAS  Google Scholar 

  • Moore, G.P.M., 1971, DNA-dependent RNA synthesis in fixed cells during spermatogenesis in mouse, Exp. Cell Res. 68:462.

    Article  PubMed  CAS  Google Scholar 

  • Nesbitt, M.N., and Francke, U., 1973, A system of nomenclature for band patterns of mouse chromosome, Chromosoma 41:145.

    Article  PubMed  CAS  Google Scholar 

  • Olds, P.J., 1970, Effect of the T locus on sperm distribution in the house mouse, Biol. Reprod. 2:91.

    Article  PubMed  CAS  Google Scholar 

  • Olds, P.J., 1971a, Effect of the T locus on sperm ultrastructure in the house mouse, J. Anat. 109:31.

    CAS  Google Scholar 

  • Olds, P.J., 1971b, Effect of the T locus on fertilization in the house mouse,J. Exp. Zool. 177:417.

    Article  CAS  Google Scholar 

  • Petras, M.L., 1967, Studies of natural populations of Mus. II. Polymorphism at the T locus, Evolution 21:446.

    Google Scholar 

  • Polani, P.E., 1972, Centromere localization at meiosis and the position of chiasmata in the male and female mouse, Chromosoma 36:342.

    Article  Google Scholar 

  • Prakash, S., 1972, Origin of reproductive isolation in the absence of apparent genic differentiation in a geographic isolate of Drosophila pseudoobscura, Genetics 72:143.

    PubMed  CAS  Google Scholar 

  • Rajasekarasetty, M.R., 1954, Studies on a new type of genetically determined quasi-sterility in the house mouse, Fertil. Steril. 5:68.

    PubMed  CAS  Google Scholar 

  • Roderick, T.H., and Davisson, M.T., 1978, Private communication: Linkage map of the mouse, Mouse News Lett. 59:5.

    Google Scholar 

  • Schnedl, W., 1971, The karyotype of the mouse, Chromosoma 35:111.

    Article  PubMed  CAS  Google Scholar 

  • Searle, A.G., 1974, Nature and consequences of induced chromosome damage in mammals, Genetics 78:173.

    PubMed  CAS  Google Scholar 

  • Searle, A.G., Beechey, C.V., and Evans, E.P., 1978, Meiotic effects in chromosomally derived male sterility of mice, Ann. Biol. Anim. Biochem. Biophys. 18(2B):391.

    Article  Google Scholar 

  • Snell, G.D., 1968, The H-2 locus of the mouse: Observations and speculations concerning its comparative genetics and its polymorphism, Fol. Biol. (Prague) 14:335.

    CAS  Google Scholar 

  • Vandeberg, J.L., and Klein, J., 1978, Localization of mouse Pgk-2 gene at the D end of the H-2 complex, J. Exp. Zool. 203:319.

    Article  PubMed  CAS  Google Scholar 

  • Vandeberg, J.L., Cooper, D.W., and Close, P.J., 1973, Mammalian testis phosphoglycerate kinase, Nature (London) New Biol. 243:48.

    CAS  Google Scholar 

  • Vandeberg, J.L., Cooper, D.W., and Close P.J., 1976, Testis specific phosphoglycerate kinase B in mouse,J. Exp. Zool. 198:231.

    Article  PubMed  CAS  Google Scholar 

  • Vojtišková, M., and Pokorna, Z., 1972. Developmental expression of H-2 antigens in the spermatogenic cell series: Possible bearing on haploid gene action, Folia Biol. (Prague) 18.1

    Google Scholar 

  • Vojtišková, M., Pokorná, Z., Viklicky, V., Boubelik, M., and Hattikudur, N.S., 1974, The expression of H-2 and differentiation antigens on mouse spermatozoa, Folia Biol. (Prague) 20:321.

    Google Scholar 

  • Vojtišková, M., Viklicky, V., Voráčová, B., Lewis, S.E., and Glueksohn-Waelsch, S., 1976, The effects of a t-allele (tAE5) in the mouse on the lymphoid system and reproduction, J. Embryol. Exp. Morphol. 36:443.

    PubMed  Google Scholar 

  • Wudl, L.R., and Sherman, M.I., 1976, In vitro studies of mouse embryos bearing mutations at the T locus: tw5 and t12, Cell 9:523.

    Article  PubMed  CAS  Google Scholar 

  • Wudl, L.R., Sherman, M.I., and Hilmann, N., 1977, Nature of-lethality of t mutations in embryos, Nature (London) 270:137.

    Article  CAS  Google Scholar 

  • Yanagisawa, K., Bennett, D., Boyse, E.A., Dunn, L.C., and Dimeo, A., 1974, Serological identification of sperm antigens specified by lethal t-alleles in the mouse, Immunogenetics 1:57.

    Article  Google Scholar 

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  1. Institute of Molecular Genetics, Czechoslovak Academy of Sciences, 142 20, Prague 4, Czechoslovakia

    Jiří Forejt

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  1. Scripps Clinic and Research Foundation, La Jolla, California, USA

    Ralph A. Reisfeld  & Soldano Ferrone  & 

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Forejt, J. (1981). Hybrid Sterility Gene Located in the T/t-H-2 Supergene on Chromosome 17. In: Reisfeld, R.A., Ferrone, S. (eds) Current Trends in Histocompatibility. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3758-4_6

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  • DOI: https://doi.org/10.1007/978-1-4684-3758-4_6

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