Abstract
Although luteinizing-hormone-releasing hormone (LH-RH) can induce ovulation in the animal (Schally and Arimura, 1977) and in some cases in the human (Nillius, 1976), it has recently been demonstrated that this hypothalamic hormone, as well as potent agonistic analogues, have antifertility effects in the animal. The administration of LH-RH or its agonistic analogue [D-Ala6,des-Gly-NH2 10] LH-RH ethylamide on diestrus I or II in normal female rats has been shown to delay the expected day of mating and vaginal cornification (Banik and Givner, 1975; Beattie and Corbin, 1977; Ferland et al.,1978; Kledzik et al.,1978a). Gonado-tropin-releasing peptides also have potent postcoital contraceptive activity in female rats (Corbin et al.,1976; Humphrey et al.,1976; Kledzik et al., 1978b) and rabbits (Hilliard et al., 1976).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Banik, V.K., and Givner, M.L., 1975, Ovulation, induction and antifertility effects of an LH-RH analog (AY-25,205) in cycling rats, J. Reprod. Fertil. 44: 87.
Beattie, C.W., and Corbin, A., 1977, Pre-and post-coital contraceptive activity of LHRH in the rat, Biol. Reprod. 16: 333.
Bex, F.J., and Corbin, A., 1979, LHRH or LHRH agonist-induced termination of pregnancy in hypophysectomized rats: Extrapituitary site of action, Endocrinology Society Meeting, Abstract A236.
Casper, R.F., and Yen, S.S.C., 1979, Induction of luteolysis in the human with a long-acting analog of luteinizing hormone-releasing factor, Science 205: 408.
Conti, M., Harwood, J.P., Hsueh, A.J.W., Dufau, M.L., and Catt, K.J., 1976, Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary, J. Biol Chem. 251: 7729.
Corbin, A., Beattie, C.W., Yardley, J., and Toell, T.J., 1976, Postcoital contraceptive effects of an agonistic analogue of luteinizing hormone-releasing hormone, Endocr. Res. Commun. 2: 359.
Ferland, L., Auclair, C., Labrie, F., Raynaud, J.P., and Azadian-Boulanger, G., 1978, Effets inhibiteurs de la LH-RH sur les récepteurs ovariens de la LH chez la rate, C.R. Acad. Sci. Ser D 286: 1113.
Gore, B.Z., Caldwell, B.V., and Speroff, L., 1973, Estrogen-induced human luteolysis, J. Clin. Endocrinol. Metab. 36: 615.
Hilliard, J., Pang, C.N., and Sawyer, C.H., 1976, Effects of luteinizing hormone-releasing hormone on fetal survival in pregnant rabbits, Fertil. Steril. 27: 421.
Hsueh, A.J.W., and Erickson, G.F., 1979, Extrapituitary action of gonadotropin-releasing hormone: Direct inhibition of ovarian steroidogenesis, Science 204: 854.
Humphrey, R.R., Windsor, B.L., Bousley, F.G., and Edgren, R.A., 1976, Antifertility effects of an analog of luteinizing hormone-releasing hormone (LHRH) in rats, Contraception 14: 625.
Hunzicker-Dunn, M., and Birnbaumer, L., 1976, Adenyl cyclase activities in ovarian tissues. IV. Gonadotropin-induced desensitization of the luteal adenylyl cyclase throughout pregnancy and pseudo-pregnancy in the rabbit and the rat, Endocrinology 99: 221.
Kledzik, G.S., Cusan, L., Auclair, C., Kelly, P.A., and Labrie, F., 1978a, Inhibition of ovarian LH and FSH receptor levels by treatment with [D-Alah, des-Gly-NH21]LHRH ethylamide during the estrous cycle in the rat, Fertil. Steril. 30: 348.
Kledzik, G.S., Cusan, L., Auclair, C., Kelly, P.A., and Labrie, F., 1978b, Inhibitory effect of a luteinizing hormone (LH)-releasing hormone agonist on rat ovarian LH and follicle-stimulating hormone receptor levels during pregnancy, Fertil. Steril. 29: 560.
Kramer, C.Y., 1956, Extension of multiple-range test to group means with unequal numbers of replications, Biometrics 12: 307.
Koyama, T., Takayoshi, O., Takahino, K., and Motoi, S., 1978, Effect of postovulatory treatment with a luteinizing hormone-releasing hormone analog on the plasma level of progesterone in women, Fertil. Steril. 30: 549.
Labrie, F., Auclair, C., Cusan, L., Lemay, A., Bélanger, A., Kelly, P.A., Ferland, L., Kledzik, G., Azadian-Boulanger, G., and Raynaud, J.Y., 1979, Inhibitory effects of treatment with LHRH or its agonists on ovarian receptor levels and function, in: Ovarian Follicular and Corpus Luteum Function, Advances in Experimental Biology and Medicine, Vol. 112 ( C.P. Channing, J. Marsh, and W. Sadler, eds.), pp. 687–693, Plenum Press, New York.
Lemay, A., Labile, F., Raynaud, J.P., and Azadian-Boulanger, G., 1978, Action lutéolytique de la LHRH chez la femme, C.R. Acad. Sci. 286: 527–529.
Lemay, A., Labrie, F., Ferland, L. and Raynaud, J.Y., I979a, Possible luteolytic effects of luteinizing hormone (LH)-releasing hormone in normal women, Fertil. Steril. 31:29–34.
Lemay, A., Labrie, F., Bélanger, A., and Raynaud, J.P., 1979b, Luteolytic effect of intranasal administration of [D-Ser(TBU)“,des-Gly-NHz’°]LHRH ethylamide in normal women, Fenil. Steril. 32: 646–651.
Moor, R.M., Rowson, L.E., Hay, M.F., and Caldwell, B.V., 1968, The effect of exogenous gonadotrophins on the conceptus and corpus luteum in pregnant sheep, J. Endocrinol. 44: 217.
Nillius, S.J., 1976, Therapeutic use of luteinizing hormone-releasing hormone in the human female, in: Hypothalamus and Endocrine Functions ( F. Labrie, J. Meites, and G. Pelletier, eds.), pp. 93–112, Plenum Press, New York.
Raynaud, J.Y., Azadian-Boulanger, G., Mary, I., Mouren, M., Lemay, A., Ferland, L., Auclair, C., and Labrie, F., 1978, Action lutéolytique de la LHRH chez la rate, la guenon et la femme, in: L’implantation de l’Oeuf ( F. Du Mesnil du Buisson, A. Psychoyos, and K. Thomas, eds.), pp. 273–283, Masson, Paris.
Raynaud, J.P., Mary, I., Moguilewsky, M., Mouren, M., and Labrie, F., 1980, Inhibition of progesterone secretion in luteal phase by 2 LHRH agonists, Fertil. Steril. 34: 593–598.
Rodbard, D., and Lewald, J.E., 1970, Computer analysis of radioligand assay and radioimmunoassay data, in: Second Karolinska Symposium on Research Methods in Reproductive Endocrinology (E. Diczfalusy, ed.), p. 79, Bogtrykheriet Forum, Copenhagen.
Sandow, J., Recherberg, W.V., ‘Oiling, W., Hahn, M., Jerzabek, G., and Frazer, H., 1978, Physiological studies with highly active analogues of LHR, in: Hypothalamic Hormones: Chemistry, Physiology and Clinical Applications ( D. Gupta and W. Voelter, eds.), pp. 307–326, Verlag Chemie-Weinheim, New York.
Schally, A.V., and Arimura, A., 1977, Physiology and nature of hypothalamic regulatory hormones, in: Clinical Neuroendocrinology ( L. Martini and G.M. Besser, eds.), pp. 1–42, Academic Press, New York.
Spies, H.G., Coon, L.L., and Gier, H.T., 1966, Luteolytic effect of LH and hCG on the corpora lutea of pseudopregnant rabbits, Endocrinology 78: 67.
Wiegelman, W., Solbach, H.G., Kley, M.K., Nieschlag, E., Rudorff, K.H., and Kruskemper, M.L., 1978, A new LHRH analogue: [D-Ser(TBU)“]LHRH-(1–9)nonapeptide ethylamide, in: Hypothalamic Hormones: Chemistry, Physiology and Clinical Applications ( D. Gupta and Voelter, M. eds.), pp. 327–333, Verlag Chemie-Weinheim, New York.
Yang, W.H., and Chang, M.C., 1968, Interruption of pregnancy in the rat and hamster by administration of PMS or hCG, Endocrinology 83: 217.
Ying, S.Y., and Guillemin, R., 1979, [D-Trp6-Pro9-NET)-luteinizing hormone-releasing factor inhibits follicular developmental in hypophysectomized rats, Nature (London) 280: 593.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Lemay, A., Labrie, F., Raynaud, J.P. (1981). Induction of Menstruation Following Subcutaneous Injection of LH-RH and Intranasal Administration of [D-Ser(TBU)6 des-Gly-NH2 10]LH-RH Ethylamide after Ovulation in Normal Women. In: McKerns, K.W. (eds) Reproductive Processes and Contraception. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3824-6_4
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3824-6_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3826-0
Online ISBN: 978-1-4684-3824-6
eBook Packages: Springer Book Archive