Abstract
Thiamine deficiency (TD) in humans causes a well known clinical syndrome in which cerebellar ataxia, ophthalmoplegia and mental changes prevail (Wernicke’s encephalopathy). Some patients, who survive this acute encephalopathy, develop a characteristic chronic amnestic syndrome (Korsakoff’s psychosis). Experimental thiamine deficiency, produced acutely with thiamine analogs (pyrithiamine) or chronically with deficient diet, can result in neurological manifestations and brain pathologic changes resembling those seen in patients with Wernicke’s encephalopathy (Dreyfus, 1976). Therefore, such animal models have been used extensively to study the effects of TD in the nervous system.
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© 1981 Plenum Press, New York
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Plaitakis, A., Nicklas, W.J., Van Woert, M.H., Hwang, E.C., Berl, S. (1981). Uptake and Metabolism of Serotonin and Amino Acids in Thiamine Deficiency. In: Haber, B., Gabay, S., Issidorides, M.R., Alivisatos, S.G.A. (eds) Serotonin. Advances in Experimental Medicine and Biology, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3860-4_23
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DOI: https://doi.org/10.1007/978-1-4684-3860-4_23
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