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Cytoplasmic Inheritance of Chloramphenicol Resistance in Mammalian Cells

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Techniques in Somatic Cell Genetics

Abstract

Chloramphenicol (CAP) resistance was the first cytoplasmic drug resistance marker to be described for mammalian cells. CAP and a variety of structurally related analogs (Fig. 1) are potent inhibitors of both bacteria and mammalian cells. Inhibition of bacterial growth is rapid, but inhibition of mammalian cell replication requires several generations (Spolsky and Eisenstadt, 1972; Bunn et al., 1974; D. C. Wallace et al., 1975).

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  1. Department of Genetics, School of Medicine, Stanford University, Stanford, California, 94305, USA

    Douglas C. Wallace

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  1. Douglas C. Wallace
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  1. The University of Texas Health Science Center at Dallas, Dallas, Texas, USA

    Jerry W. Shay

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© 1982 Plenum Press, New York

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Wallace, D.C. (1982). Cytoplasmic Inheritance of Chloramphenicol Resistance in Mammalian Cells. In: Shay, J.W. (eds) Techniques in Somatic Cell Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4271-7_12

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  • DOI: https://doi.org/10.1007/978-1-4684-4271-7_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4273-1

  • Online ISBN: 978-1-4684-4271-7

  • eBook Packages: Springer Book Archive

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