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Development and Regulation of Cardiac Muscarinic Acetylcholine Receptor Number, Function and Gyanyl Nucleotide Sensitivity

  • Chapter
Myocardial Injury

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 161))

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Abstract

Acetylcholine is released from parasympathetic nerve terminals and binds to muscarinic acetylcholine (mACh) receptors to elicit negative chronotropic and inotropic effects on the heart. The molecular mechanisms for these cardiac effects are not well understood. Investigation of the mACh receptor has been greatly facilitated by the development of the potent cholinergic antagonist [3H] quinuclidinyl benzilate (QNB) which binds specifically and with high affinity to the mACh receptor (1). [3H]QNB can be used to study the interaction of agonists and antagonists with the receptor and quantitate the number of receptors present in cells and tissues.

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Authors and Affiliations

  1. Department of Pharmacology, University of Washington, Seattle, Washington, 98195, USA

    Stan W. Halvorsen, Bronia Engel, Dale D. Hunter & Neil M. Nathanson

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  1. Stan W. Halvorsen
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  2. Bronia Engel
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  3. Dale D. Hunter
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  4. Neil M. Nathanson
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Editor information

Editors and Affiliations

  1. Louisiana State University Medical Center, New Orleans, Louisiana, USA

    John J. Spitzer

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© 1983 Plenum Press, New York

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Halvorsen, S.W., Engel, B., Hunter, D.D., Nathanson, N.M. (1983). Development and Regulation of Cardiac Muscarinic Acetylcholine Receptor Number, Function and Gyanyl Nucleotide Sensitivity. In: Spitzer, J.J. (eds) Myocardial Injury. Advances in Experimental Medicine and Biology, vol 161. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4472-8_8

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  • DOI: https://doi.org/10.1007/978-1-4684-4472-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4474-2

  • Online ISBN: 978-1-4684-4472-8

  • eBook Packages: Springer Book Archive

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