Abstract
The pharmacokinetics of antibiotics are often studied by means of microbiological assays. However this is subject to some uncertainty if the drug is metabolized to species having a different spectrum of antimicrobial activity compared with the parent. For basic pharmacokinetic work therefore it is desirable to use a method which separates parent drug from active metabolites and preferably quantitates the metabolites in addition.
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© 1983 Plenum Press, New York
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Chamberlain, J., Dell, D., Coppin, F.G. (1983). A Note on HPLC Determination of Cefotaxime and Its Metabolites. In: Reid, E., Leppard, J.P. (eds) Drug Metabolite Isolation and Determination. Methodological Surveys in Biochemistry and Analysis, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4484-1_31
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DOI: https://doi.org/10.1007/978-1-4684-4484-1_31
Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4684-4484-1
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